Evidence map›Paper›PMID 39876967›Full record

ArticleArchives of endocrinology and metabolism2024

Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats.

Md Iqbal Alam, Naba Sami, Aftab Alam, Sheema Wazib, Neha Dhyani, Sher Afghan, Mairaj Ahmed Ansari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Basic and translational endocrinology.Archives of endocrinology and metabolism · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Md Iqbal AlamJamia Hamdard University Hamdard Institute of Medical Sciences and Research Department of Physiology New Delhi India Department of Physiology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard University, New Delhi.ORCID https://orcid.org/0000-0002-3285-7282
Naba SamiJamia Hamdard University Hamdard Institute of Medical Sciences and Research Department of Physiology New Delhi India Department of Physiology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard University, New Delhi.ORCID https://orcid.org/0000-0002-7479-2384
Aftab AlamCoventry University School of Life Sciences Coventry UK School of Life Sciences, Coventry University, Coventry, UK.ORCID https://orcid.org/0000-0001-8089-6721
Sheema WazibJamia Hamdard University Hamdard Institute of Medical Sciences and Research Department of Physiology New Delhi India Department of Physiology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard University, New Delhi.ORCID https://orcid.org/0009-0006-9734-3238
Neha DhyaniJamia Hamdard University Hamdard Institute of Medical Sciences and Research Department of Physiology New Delhi India Department of Physiology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard University, New Delhi.ORCID https://orcid.org/0000-0003-0853-5758
Sher AfghanJamia Hamdard University Hamdard Institute of Medical Sciences and Research Department of Physiology New Delhi India Department of Physiology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard University, New Delhi.ORCID https://orcid.org/0009-0000-1598-4709
Mairaj Ahmed AnsariJamia Hamdard School of Chemical & Life Sciences Department of Biotechnology New Delhi India Department of Biotechnology, School of Chemical & Life Sciences, Jamia Hamdard, New Delhi.ORCID https://orcid.org/0000-0003-0040-4147

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aims to explore the role of estrogen in providing cardioprotective benefits to premenopausal women, examining how hormonal differences between sexes influence the prevalence of cardiovascular diseases (CVDs) in women. Materials and methods: Eighteen female Wistar rats were equally distributed into three treatment groups. Animals in Group I (sham-operated) and Group II (ovariectomized [OVX]) received oral saline solution at a dose of 2 mL/kg. Group III (OVX+E Results: The OVX group, compared with the sham-operated group, displayed significantly altered hemodynamic parameters and baroreflex sensitivity, along with elevated MDA levels and decreased SOD and NO levels. This group also had higher levels of inflammatory cytokines than the sham-operated group. In the absence of estrogen, these factors led to the advancement of cardiovascular abnormalities. In the OVX+E Conclusion: Estrogen mediates cardioprotection by improving baroreflex sensitivity in ovariectomized Wistar rats through modulation of the NO pathway.

Indexed as

BaroreflexEstradiolEstrogensInflammationAnimalsBiomarkersFemaleHemodynamicsInterleukin-6MalondialdehydeNitric OxideOvariectomyRatsRats, WistarSuperoxide DismutaseTumor Necrosis Factor-alphaBiomarkersEstradiolEstrogensInterleukin-6MalondialdehydeNitric OxideSuperoxide DismutaseTumor Necrosis Factor-alphabaroreflex sensitivityCardiovascular diseasesestrogeninflammatory cytokinesovariectomyoxidative stress

Identifiers

PMID39876967
PMCPMC11771758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.