ArticleJournal of medical biochemistry2024
Influence mechanism of serum free immunoglobulin light chain on pulmonary inflammatory response and serum levels of inflammatory factors in patients with chronic obstructive pulmonary disease.
Article in Journal of medical biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Influence of Genetic and Epigenetic Factors on Periodontitis Susceptibility and Treatment Outcomes.Biochemical genetics · 2026Review
- Biochemical and clinical effects of continuous positive airway pressure combined with sildenafil on inflammatory and hemodynamic profiles in obese asthma patients with pulmonary arterial hypertension.Journal of medical biochemistry · 2026Article
- Increased total plasma TGF-β1 levels and deregulated IgA-IgM axis in chronic obstructive pulmonary disease.Journal of medical biochemistry · 2026Article
- Investigate the effect of oxygen-driven salbutamol combined with methylprednisolone on bronchial asthma from the perspective of serum molecular markers.Journal of medical biochemistry · 2026Article
- An investigation of the correlation between IL-8, IL-10 and nutritional proteins in patients with sleep disorders in chronic obstructive pulmonary disease.Journal of medical biochemistry · 2025Article
- Predictive value of serological markers and immune indicators combined with early warning scoring system for prognosis in pediatric acute respiratory infections.Journal of medical biochemistry · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is not fully understood. This work aimed to demonstrate the role of serum free light chains (sFLC) in the pulmonary inflammatory response of COPD patients and its relationship with serum inflammatory cytokine (IC) levels. Methods: Eighty subjects were enrolled, including 40 COPD patients (COPD group) and 40 healthy controls (control group). All patients were further rolled into four subgroups regarding the Global Initiative for Chronic Obstructive Lung Disease (GOLD) staging criteria. The serum levels of sFLC and ICs were compared between the two groups, and their correlations with lung function indicators were analyzed. Results: The serum sFLC levels of COPD patients were markedly superior to those of healthy controls. The levels of serum sFLC and ICs (tumour necrosis factor-a (TNF-a), interleukin (IL)-6, IL-8) gradually increased with the severity of the disease. The levels of ICs were negatively correlated with lung function indicators (FEV1% predicted, FEV1/FVC). Conclusions: These findings suggest that serum sFLC may play a critical role in the pulmonary inflammatory response of COPD patients and serve as a potential indicator for evaluating COPD severity and predicting disease progression.
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