ArticleFrontiers in medicine2024
Salivary alpha-amylase activity and its association with early childhood caries and rampant caries experience: a cross-sectional study.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Salivary gland function and redox status in young adult male rats treated with the psychostimulant short-release methylphenidate.Odontology · 2026Article
- Association between miR-21 polymorphism and the risk of primary dental caries in preschool children.Odontology · 2026Article
- Mapping the ECC-Saliva Neuroimmune Axis Using AI: A System-Level Framework.Children (Basel, Switzerland) · 2026Article
- Biosensors in dental, oral and craniofacial applications.Npj biosensing · 2026Review
- Examination of the Communication Environment When Applying Removable Dentures as Wearable Devices.Cureus · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
Aims: This study aims to evaluate salivary alpha-amylase levels in children diagnosed with Early Childhood Caries (ECC) and Rampant Caries (RC) and compare them to levels in children without ECC or RC. It also examines the relationship between salivary alpha-amylase levels and increased caries activity in the children with ECC or RC. Materials and methods: A cross-sectional study was conducted at RAK College of Dental Sciences (RAKCODS) with 100 children aged 3-12 years. Participants were divided into ECC and RC groups, each consisting of study and control groups. Salivary alpha-amylase levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA) kits. Statistical analyses, including the Wilcoxon Signed Rank test and Pearson's correlation coefficient, were performed using SPSS version 29 to compare salivary alpha-amylase levels between groups and examine correlation with severity of dental caries. Results: The study found that children with ECC and RC had significantly higher mean salivary alpha-amylase levels (16.046 U/mL and 20.62 U/mL, respectively) compared to control groups (5.09 U/mL and 12.70 U/mL). The differences were statistically significant ( Conclusion: The study concludes that elevated salivary alpha-amylase levels, which are statistically significant, are observed in children with ECC and RC. Additionally, it was found that salivary alpha-amylase levels increased with the number of carious lesions. These findings suggest that salivary alpha-amylase could serve as a valuable biomarker for assessing caries risk and guiding preventive strategies.
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