Evidence map›Paper›PMID 39876792›Full record

ArticleJournal of the Royal Society, Interface2025

Multicellular PID control for robust regulation of biological processes.

Vittoria Martinelli, Davide Fiore, Davide Salzano, Mario di Bernardo

Abstract read
In one paragraph

Article in Journal of the Royal Society, Interface, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Vittoria MartinelliDepartment of Mathematics and Applications, 'R. Caccioppoli' University of Naples Federico II Via Cintia Monte S.Angelo, Naples 80126, Italy.ORCID 0000-0002-9891-7970
Davide FioreDepartment of Mathematics and Applications, 'R. Caccioppoli' University of Naples Federico II Via Cintia Monte S.Angelo, Naples 80126, Italy.ORCID 0000-0002-4011-5836
Davide SalzanoSSM- School for Advanced Studies Via Mezzocannone 4, Naples 80138, Italy.ORCID 0000-0003-3560-8609
Mario di BernardoSSM- School for Advanced Studies Via Mezzocannone 4, Naples 80138, Italy.ORCID 0000-0002-2171-4745

Funding

HubLife Science - Digital Health (LSH-DH) PNC-E3-2022-23683267 - DHEAL- COM
6 · The paper itself

Abstract

This article presents the first implementation of a proportional-integral-derivative (PID) biomolecular controller within a consortium of different cell populations, aimed at robust regulation of biological processes. By leveraging the modularity and cooperative dynamics of multiple engineered cell populations, we develop a comprehensive

Indexed as

Escherichia coliModels, BiologicalComputer Simulationbiological controlgenetic regulatory systemsproportional-integral-derivative controlsynthetic biology

Identifiers

PMID39876792
PMCPMC11775662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.