ArticleClinical implant dentistry and related research2025
Salivary Inflammatory Mediator Profiles in Periodontal and Peri-Implant Health and Disease: A Cross-Sectional Study.
Article in Clinical implant dentistry and related research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Machine learning-based analysis of oral rinse samples to identify candidate proteomic signatures for severe periodontitis: a pilot study.Scientific reports · 2026Article
- Heavy Metal-Driven Oral Dysbiosis: Salivary Toxicometallomics at the Host-Microbiome Interface Across Pathologies.Life (Basel, Switzerland) · 2026Review
- Integration of periodontal pathogens and inflammatory mediators in saliva as biomarkers for periodontitis.Frontiers in cellular and infection microbiology · 2026Article
- Noninvasive salivary biomarkers (PTX3, calprotectin, and IL-8) for early-onset neonatal pneumonia: case-control differences and exploratory discrimination.Frontiers in pediatrics · 2026Article
- Early peri-implant crevicular fluid interleukin-1β as a potential predictor of peri-implant diseases: a 12-month prospective study.Frontiers in medicine · 2026Article
- Comparative Analysis of Salivary and Serum Inflammatory Mediator Profiles in Patients With Rheumatoid Arthritis and Periodontitis.Mediators of inflammation · 2025Article
- A scoping review of diagnostic techniques used for the detection of peri-implantitis around endosseous dental implants.Frontiers in dental medicine · 2025Review
- Assessment of salivary biomarkers in early peri-implantitis detection.Bioinformation · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
objectiveThis cross-sectional study aimed to investigate the salivary profile of inflammatory mediators in individuals with periodontal and peri-implant disease as compared to individuals with periodontal and peri-implant health. MATERIALS AND
methodsSaliva samples were collected from 155 participants (mean age 63.3 ± 11.4 years), comprising individuals with periodontal and peri-implant health (N = 41), gingivitis and/or mucositis (N = 18), and periodontitis and/or peri-implantitis (N = 96). Samples were analyzed using multiplex-immunoassay panel consisting of inflammatory mediators in the tumor necrosis factor (TNF), interferon (IFN), interleukin (IL) superfamily, and matrix metalloproteinases.
resultsThe levels of B-cell activating factor (BAFF), sIL-6Rβ, IFN-β, and sIL-6Rα, sTNFR1, and Pentraxin-3 were significantly higher in patients with periodontitis and/or peri-implantitis compared to healthy subjects. Furthermore, among the investigated inflammatory mediators, Pentraxin-3 exhibited the highest diagnostic potential (AUC = 0.74) for distinguishing between subjects with periodontitis and/or peri-implantitis and healthy individuals.
conclusionsOur findings demonstrated elevated salivary levels of BAFF, sIL-6Rβ, IFN-β, sIL-6Rα, sTNF-R1, and Pentraxin-3 in individuals with periodontitis and/or peri-implantitis in comparison to periodontal and peri-implant healthy controls.
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