ArticleOptics express2025
Modal focal adaptive optics for Bessel-focus two-photon fluorescence microscopy.
Article in Optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Polarization-engineered aberration-resilient light sheet microscopy.bioRxiv : the preprint server for biology · 2026Article
- Hadamard based single-pixel microscopy using sensor-less adaptive optics supported by multi-actuator adaptive lens.Nature communications · 2025Article
- Compact way to generate guide star for wavefront sensing in Bessel two-photon microscopy.Scientific reports · 2025Article
- Axicons for improved resolution and depth of focus in adaptive optics scanning light ophthalmoscopy.Biomedical optics express · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
Adaptive optics (AO) improves the spatial resolution of microscopy by correcting optical aberrations. While its application has been well established in microscopy modalities utilizing a circular pupil, its adaptation to systems with non-circular pupils, such as Bessel-focus two-photon fluorescence microscopy (2PFM) with an annular pupil, remains relatively uncharted. Herein, we present a modal focal AO (MFAO) method for Bessel-focus 2PFM. Measuring and correcting aberration using a spatial light modulator placed in conjugation with the focal plane of the microscope objective, MFAO employs Zernike annular polynomials - a first in AO implementation - to achieve performance on par with a previous zonal AO method, but with a notably simplified optical configuration. We validated the performance of MFAO in correcting artificial and sample-induced aberrations, as well as in
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