ArticleMicrobiome2025
Reductive acetogenesis is a dominant process in the ruminant hindgut.
Article in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Formate- and Sodium Ion-Dependent Wood-Ljungdahl Pathway Involved in Organo-, Litho-, and Methylotrophic Growth of Tepidanaerobacter acetatoxydans.Environmental science & technology · 2026Article
- Dietary Astragalus and Fermented Astragalus in Postpartum Turpan Black Ewes: Impacts on Maternal Health, Rumen Microbiota, Lactation, and Lamb Development.Microorganisms · 2026Article
- Effects ofAnimals : an open access journal from MDPI · 2026Article
- Challenges in redirecting rumen hydrogen flow in vitro: insights from new hydrogenotrophic isolates.BMC microbiology · 2026Article
- Differential rumen and hindgut microbiome and metabolome in Holstein female calves with divergent feed efficiency.Microbiome · 2026Article
- Reprogramming hydrogen metabolism for methane mitigation in dairy cows: mechanistic insights from polyphenols using meta-omics approaches.NPJ biofilms and microbiomes · 2026Article
- Metagenomic insights into the global wild boar faecal microbiome reveal novel taxa and carbohydrate degraders distinguishing wild and domesticated Sus.Microbiome · 2026Article
- Metagenomic analysis of fecal microbiomes reveals genetic potential for diverse hydrogen management strategies in marsupials.mSystems · 2026Article
- Metagenomic and metabolomic analyses of rumen fiber digestion in Mongolian cattle fed fresh grass versus hay.Microbiology spectrum · 2026Article
- Effects of Dietary Spirulina Supplementation on Cecal Microbiota, Serum Biochemistry, and Antioxidant Capacity in Lambs.Microorganisms · 2026Article
- Article
- Sugar-inducible promoters for manipulation of core metabolic pathways in the thermophilic acetogenApplied and environmental microbiology · 2025Article
- Melatonin Enhances Muscle Development and Suppresses Fat Deposition in Cashmere Goats by Implicating Gut Microbiota and Ameliorating Systemic Antioxidant Status.Antioxidants (Basel, Switzerland) · 2025Article
- Spatial Multi-Omics Analysis of the Qianqiu Goat Gut Microbiome and Metabolome.International journal of molecular sciences · 2025Article
- Metabolic versatility enables acetogens to colonize ruminants with diet-driven niche partitioning.The ISME journal · 2025Article
- GCompip: a pipeline for estimating the gene abundance in microbial communities.Bioinformatics advances · 2025Article
- Effects of dietary supplementation with different levels of rose pomace on rumen bacterial diversity and fermentation, and longissimus dorsi fatty acids in Hu sheep.Frontiers in microbiology · 2025Article
- Triadic relationships between pasture exposure, gastrointestinal parasites, and hindgut microbiomes in grazing lambs.PloS one · 2025Article
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe microbes residing in ruminant gastrointestinal tracts play a crucial role in converting plant biomass to volatile fatty acids, which serve as the primary energy source for ruminants. This gastrointestinal tract comprises a foregut (rumen) and hindgut (cecum and colon), which differ in structures and functions, particularly with respect to feed digestion and fermentation. While the rumen microbiome has been extensively studied, the cecal microbiome remains much less investigated and understood, especially concerning the assembling microbial communities and overriding pathways of hydrogen metabolism.
resultsTo address this gap, we comparatively investigated the composition, capabilities, and activities of the rumen and the cecum microbiome using goats as an experimental ruminant model. In situ measurements showed significantly higher levels of dissolved hydrogen and acetate in the cecum than in the rumen. Increased dissolved hydrogen indicated distinct processes and reduced coupling between fermentative H
conclusionsThese findings highlight an enrichment of acetogenesis in a key region of the gastrointestinal tract and reshape our understanding of ruminant hydrogen metabolism and how the H
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