Evidence map›Paper›PMID 39875919›Full record

ArticleJournal of neuroinflammation2025

NLRX1 limits inflammatory neurodegeneration in the anterior visual pathway.

Alexander J Gill, Matthew D Smith, Danny Galleguillos, Thomas Garton, Jackson W Mace, Sachin P Gadani, Swati Kumar, Aayush Pokharel, Krista Solem, Saahith Potluri and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexander J GillDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Matthew D Smith *Department of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Danny Galleguillos *Department of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Thomas GartonDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Jackson W MaceDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Sachin P GadaniDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Swati KumarDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Aayush PokharelDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Krista SolemDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Saahith PotluriDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Omar HusseinDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Giuliana Sardi RoginesDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Arihant SinghDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Annatje ClarkDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
Peter A CalabresiDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA. pcalabr1@jhmi.edu.
Marjan GharagozlooDepartment of Neurology, Division of Neuroimmunology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA. mgharag1@jh.edu.

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
The Role of KV1.3 in Effector T cellsR01NS041435 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI CALABRESI, PETER A · 2000 to 2025
$5.8M
Mechanisms by which effector T cells modulate endogenous remyelinationR37NS041435 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CALABRESI, PETER A · 2013 to 2019
$3.0M
Inhibition of MIF nuclease-mediated parthanatos prevents neuron and oligodendrocyte death in the context of multiple sclerosisF31NS132520 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Jackson Mace · 2024 to 2026
$132k
Karen Toffler Charitable Trust 90105789National Multiple Sclerosis Society FAN-2007-36944National Multiple Sclerosis Society FAN-2106-37832National Multiple Sclerosis Society RG-1907-34756National Multiple Sclerosis Society TA-2104-37423NIGMS NIH HHS T32 GM136577NIH HHS T32 GM136577NINDS NIH HHS F31 NS132520NINDS NIH HHS F31NS132520NINDS NIH HHS R01 NS041435NINDS NIH HHS R37 NS041435R01, NIH NS041435Race to Erase MS 147096
6 · The paper itself

Abstract

Chronic innate immune activation in the central nervous system (CNS) significantly contributes to neurodegeneration in progressive multiple sclerosis (MS). Using multiple experimental autoimmune encephalomyelitis (EAE) models, we discovered that NLRX1 protects neurons in the anterior visual pathway from inflammatory neurodegeneration. We quantified retinal ganglion cell (RGC) density and optic nerve axonal degeneration, gliosis, and T-cell infiltration in Nlrx1

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMitochondrial ProteinsNerve DegenerationVisual PathwaysAnimalsFemaleMiceMice, Inbred C57BLMice, KnockoutRetinal Ganglion CellsMitochondrial ProteinsNLRX1 protein, mouseEAEGliaInnate immunityMSNeurodegenerationNeuroinflammationNLRX1Optic nerveRetina

Identifiers

PMID39875919
PMCPMC11773851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.