Bioactivity-guided isolation and molecular modeling of the anti-inflammatory constituents from the leaves of Duranta erecta Linn.

Marina Sobhy, Farid N Kirollos, Sameh F AbouZid, Nasser S M Ismail, Riham A El-Shiekh, Essam Abdel-Sattar

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Article in BMC complementary medicine and therapies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Marina SobhyPharmacognosy Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.

Farid N KirollosPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

Sameh F AbouZidDepartment of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt.

Nasser S M IsmailPharmaceutical Chemistry Department, Faculty of Pharmacy, Future University in Egypt (FUE), Cairo, 11835, Egypt.

Riham A El-ShiekhPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. riham.adel@pharma.cu.edu.eg.

Essam Abdel-SattarPharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt. essam.abdelsattar@pharma.cu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Duranta erecta Linn. belongs to the Verbenaceae family and is primarily found in subtropical, tropical, and temperate climates. The plant has been reported to contain a variety of phytoconstituents, including iridoid glycosides, flavonoids, flavonoid glycosides, alkaloids, phenolics, tannins, terpenoids, steroids, and saponins. In this investigation, a bioactivity-guided isolation was used to isolate cyclooxygenases (COXs) and lipoxygenase (LOX)-inhibiting compounds from the leaves of Duranta erecta Linn. Duranterectoside A (1), lamiide (2), and apigenin 4',7-dimethyl ether (3) were identified employing spectroscopic methods (including ESI-MS,

Indexed as

Anti-Inflammatory AgentsCyclooxygenase InhibitorsLipoxygenase InhibitorsPlant ExtractsModels, MolecularMolecular Docking SimulationPlant LeavesAnti-Inflammatory AgentsCyclooxygenase InhibitorsLipoxygenase InhibitorsPlant ExtractsAnti-inflammatoryBioactivity-guided isolationDuranta erecta Linn.Modelling ADME propertiesMolecular dockingMolecular dynamics

Identifiers

PMID39875865

DOI10.1186/s12906-025-04764-7

PMCPMC11773759

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