Evidence map›Paper›PMID 39875720›Full record

SynthesisJournal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing2025

The role of cardiac sympathetic denervation for ventricular arrhythmias: an updated systematic review and meta-analysis.

Daniel B Hanna, Ahmadreza Karimianpour, Nicole Mamprejew, Chris Fiechter, Dhiran Verghese, Viviana Navas, Dinesh Sharma

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniel B HannaRooney Heart Institute, 311 9th St N #201, Naples, FL, 34102, USA. danielhannamd@gmail.com.ORCID http://orcid.org/0000-0002-5068-5402
Ahmadreza KarimianpourPiedmont Heart of Buckhead, Atlanta, USA.
Nicole MamprejewRooney Heart Institute, 311 9th St N #201, Naples, FL, 34102, USA.
Chris FiechterRooney Heart Institute, 311 9th St N #201, Naples, FL, 34102, USA.
Dhiran VergheseRooney Heart Institute, 311 9th St N #201, Naples, FL, 34102, USA.
Viviana NavasRooney Heart Institute, 311 9th St N #201, Naples, FL, 34102, USA.
Dinesh SharmaRooney Heart Institute, 311 9th St N #201, Naples, FL, 34102, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe role of the sympathetic nervous system in the initiation and continuation of ventricular tachyarrhythmias (VTA) is well established. However, whether CSD reduces implantable cardioverter-defibrillator (ICD) shocks and recurrent VTA is still uncertain.

methodsA comprehensive literature search was performed at Medline and Embase until March 2023. The primary outcome was the rate of ICD shocks and VTA per patient-year in our pooled analysis of all included articles. Analyses were conducted using Comprehensive Meta-Analysis software.

resultsInitial search yielded 1324 scientific studies with a total of 15 studies fitting our inclusion criteria. ICD shocks at 1 year post-CSD revealed an event rate of 69.8% (95% CI, 56.4-80.4% with 50% heterogeneity) (I

conclusionCSD seems to be promising as an acceptable treatment strategy for recurrent VTA refractory to traditional pharmacological or ablation therapy.

Indexed as

SympathectomyTachycardia, VentricularDefibrillators, ImplantableHumansRecurrenceCardiac denervationCardiac sympathectomySympathetic denervationVentricular fibrillationVentricular tachycardia

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.