Evidence map›Paper›PMID 39875718›Full record

ArticleAnnals of surgical oncology2025

Trends in Atypical Ductal Hyperplasia Diagnosis and Upgrade: A 20-Year Experience and Impact of MRI Use on Upgrade Rates.

Shruti Zaveri, Susie X Sun, Tarek Zaghloul, Therese B Bevers, Constance T Albarracin, Miral Patel, Isabelle Bedrosian

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shruti ZaveriDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.
Susie X SunDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Tarek ZaghloulDepartment of Surgical Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.
Therese B BeversDepartment of Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Constance T AlbarracinDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Miral PatelDepartment of Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Isabelle BedrosianDepartment of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ibedrosian@mdanderson.org.ORCID http://orcid.org/0000-0002-8775-8361

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtypical ductal hyperplasia (ADH) is a benign proliferative breast lesion. Surgical excision of ADH is often recommended to rule out underlying malignant disease.

objectiveThe aim of this study was to evaluate the trends in ADH upgrade rates over time and identify the impact of magnetic resonance imaging (MRI) use on upgrade rates.

methodsRetrospective review of a prospectively maintained institutional database was used to identify women diagnosed with ADH by core needle biopsy between 2004 and 2022. Trends in ADH upgrade to in situ and invasive disease as well as clinicopathologic factors associated with upgrade were analyzed.

resultsA total of 975 ADH cases were identified between 2004 and 2022. Of these, 361 (37.0%) met our multidisciplinary criteria for excision and thus met the inclusion criteria for this study. A total of 93 (25.8%) patients were found to have upgrade on final surgical pathology. When compared across quartiles of time, there were no significant changes in overall rates of upgrade over the study time period despite changes in diagnostic modalities. In women selectively referred for excision based on standardized imaging and pathology criteria, enhancement on preoperative MRI was not found to be significantly associated with increased rates of ADH upgrade.

conclusionWhile trends in diagnostic modality of ADH have changed over time, we found that rates of ADH upgrade have remained stable over time and are not associated with imaging modality, suggesting that enhancements in imaging technology have not improved our ability to preoperatively identify patients with a concurrent malignancy.

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingMagnetic Resonance ImagingAdultAgedBiopsy, Large-Core NeedleFemaleFollow-Up StudiesHumansHyperplasiaMiddle AgedPrognosisRetrospective Studies

Identifiers

PMID39875718

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.