Evidence map›Paper›PMID 39875591›Full record

ReviewNature protocols2025

fMRI data acquisition and analysis for task-free, anesthetized rats.

Roël M Vrooman, Monica van den Berg, Gabriel Desrosiers-Gregoire, Wessel A van Engelenburg, Marie E Galteau, Sung-Ho Lee, Andor Veltien, David A Barrière, Diana Cash, M Mallar Chakravarty and 13 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Roël M VroomanDonders Institute for Brain, Behaviour, and Cognition, Nijmegen, The Netherlands.ORCID 0000-0002-2859-6681
Monica van den BergBio-imaging lab, University of Antwerp, Antwerp, Belgium.
Gabriel Desrosiers-GregoireCerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Quebec, Canada.ORCID 0000-0003-2197-1183
Wessel A van EngelenburgDonders Institute for Brain, Behaviour, and Cognition, Nijmegen, The Netherlands.
Marie E GalteauDonders Institute for Brain, Behaviour, and Cognition, Nijmegen, The Netherlands.
Sung-Ho LeeCenter for Animal MRI, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Andor VeltienDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-8090-5445
David A BarrièreUMR INRAE/CNRS 7247 Physiologie des Comportements et de la Reproduction, Physiologie de la reproduction et des comportements, Centre de recherche INRA de Nouzilly, Tours, France.
Diana CashBiomarker Research And Imaging in Neuroscience (BRAIN) Centre, Department of Neuroimaging, King's College London, London, UK.ORCID 0000-0001-5021-1234
M Mallar ChakravartyCerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Quebec, Canada.ORCID 0000-0002-0759-5508
Gabriel A DevenyiCerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Quebec, Canada.ORCID 0000-0002-7766-1187
Alessandro GozziFunctional Neuroimaging Laboratory, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy.ORCID 0000-0002-5731-4137
Olli GröhnBiomedical Imaging Unit, A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Andreas HessInstitute of Experimental and Clinical Pharmacology and Toxicology, FAU Erlangen-Nürnberg, Erlangen, Germany.
Judith R HombergDonders Institute for Brain, Behaviour, and Cognition, Nijmegen, The Netherlands.
Ileana O JelescuDepartment of Radiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0002-3664-0195
Georgios A KelirisInstitute for Computer Science, Foundation for Research and Technology - Hellas, Heraklion, Crete, Greece.
Tom ScheenenDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-4468-1480
Yen-Yu Ian ShihCenter for Animal MRI, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Marleen VerhoyeBio-imaging lab, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-6267-0611
Claire WaryBruker BioSpin MRI GmbH, Ettlingen, Germany.
Marcel ZwiersDonders Institute for Brain, Behaviour, and Cognition, Nijmegen, The Netherlands.
Joanes GrandjeanDonders Institute for Brain, Behaviour, and Cognition, Nijmegen, The Netherlands. joanes.grandjean@radboudumc.nl.ORCID 0000-0001-8413-0491

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Templates for the acquisition of large datasets such as the Human Connectome Project guide the neuroimaging community to reproducible data acquisition and scientific rigor. By contrast, small animal neuroimaging often relies on laboratory-specific protocols, which limit cross-study comparisons. The establishment of broadly validated protocols may facilitate the acquisition of large datasets, which are essential for uncovering potentially small effects often seen in functional MRI (fMRI) studies. Here, we outline a procedure for the acquisition of fMRI datasets in rats and describe animal handling, MRI sequence parameters, data conversion, preprocessing, quality control and data analysis. The procedure is designed to be generalizable across laboratories, has been validated by using datasets across 20 research centers with different scanners and field strengths ranging from 4.7 to 17.2 T and can be used in studies in which it is useful to compare functional connectivity measures across an extensive range of datasets. The MRI procedure requires 1 h per rat to complete and can be carried out by users with limited expertise in rat handling, MRI and data processing.

Indexed as

BrainImage Processing, Computer-AssistedMagnetic Resonance ImagingAnesthesiaAnimalsConnectomeRats

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.