Evidence map›Paper›PMID 39875485›Full record

ArticleNPJ precision oncology2025

Naltriben promotes tumor growth by activating the TRPM7-mediated development of the anti-inflammatory M2 phenotype.

Viviane Nascimento Da Conceicao, Yuyang Sun, Manigandan Venkatesan, Jorge De La Chapa, Karthik Ramachandran, Rahul S Jasrotia, Victor Drel, Xiufang Chai, Bibhuti B Mishra, Muniswamy Madesh and 1 more

Erratum issuedAbstract read
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Temporal immunomodulation of CD4Science advances · 2026
    Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Viviane Nascimento Da ConceicaoDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Yuyang SunDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Manigandan VenkatesanCenter for Mitochondrial Medicine, Department of Medicine/Cardiology Division, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Jorge De La ChapaDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Karthik RamachandranCenter for Mitochondrial Medicine, Department of Medicine/Cardiology Division, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Rahul S JasrotiaDepartment of Developmental Dentistry, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Victor DrelDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.ORCID http://orcid.org/0000-0003-4542-0132
Xiufang ChaiDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Bibhuti B MishraDepartment of Developmental Dentistry, University of Texas Health San Antonio, San Antonio, TX, 78229, USA.
Muniswamy MadeshCenter for Mitochondrial Medicine, Department of Medicine/Cardiology Division, University of Texas Health San Antonio, San Antonio, TX, 78229, USA. muniswamy@uthscsa.edu.
Brij B SinghDepartment of Periodontics, University of Texas Health San Antonio, San Antonio, TX, 78229, USA. singhbb@uthscsa.edu.

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
Institutional Research Training GrantT32DE014318 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Kenneth M Hargreaves · 2002 to 2026
$12.1M
TRAINING GRANT ON THE BIOLOGY OF AGINGT32AG021890 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Erzsebet Kokovay, JAMES FLOYD NELSON · 2003 to 2026
$11.4M
TRPC1, Calcium, and Saliva SecretionR01DE017102 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2006 to 2026
$7.5M
Spectral revelations of mitochondrial Ca2+ flux interactomeR01GM109882 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI MUNISWAMY, MADESH · 2014 to 2022
$3.3M
Glycolytic metabolites, Calcium entry and Sjogren’s syndromeR01DE031716 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2022 to 2026
$2.8M
Mechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLDR01DK135179 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Joseph A. Baur, MADESH MUNISWAMY · 2023 to 2026
$2.1M
Control of Endothelial Mechanotransduction by the Mitochondrial Ca2+ Uniporter: Implications for AtherosclerosisR01HL142673 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ALEVRIADOU, BARBARA RITA, MUNISWAMY, MADESH · 2018 to 2021
$2.0M
Epigenetic regulations in Sjogern's syndromeR01DE022765 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SINGH, BRIJ B · 2017 to 2021
$1.8M
NCATS NIH HHS UL1 TR001120NCI NIH HHS P30 CA054174NHLBI NIH HHS R01 HL142673NIA NIH HHS T32 AG021890NIDCR NIH HHS R01 DE017102NIDCR NIH HHS R01 DE022765NIDCR NIH HHS R01 DE031716NIDCR NIH HHS T32 DE014318NIDDK NIH HHS R01 DK135179NIGMS NIH HHS R01 GM109882U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR) R01DE017102
6 · The paper itself

Abstract

Macrophage plasticity is critical for maintaining immune function and developing solid tumors; however, the macrophage polarization mechanism remains incompletely understood. Our findings reveal that Mg

Identifiers

PMID39875485
PMCPMC11775176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.