ArticleScientific reports2025
The link between sleep bruxism and oxidative stress based on a polysomnographic study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Renalase and Total Antioxidant Status in Relation to CCTA-Assessed Coronary Artery Disease Severity in Suspected Obstructive Sleep Apnea.Antioxidants (Basel, Switzerland) · 2026Article
- Sleep Bruxism: Mapping Potential Direct and Indirect Risk Pathways in EPISONO Adult Population-Based Study.Journal of oral rehabilitation · 2026Article
- Sleep Bruxism and Hypobaric Hypoxia Exposure: Exploring the Physiological Association.Journal of clinical medicine · 2025Review
- Tenascin-C and Thrombospondin-1 as a Potential Link Between Sleep Bruxism and Cardiovascular Diseases-A Case-Control Study.Journal of clinical medicine · 2025Article
- Cardiovascular Risk Profiles of Individuals with Bruxism: A Case-Control Study Using QRISK3 Scores.Cureus · 2025Article
- Effects of Dietary and Probiotic Interventions in Patients with Metabolic Syndrome and Obstructive Sleep Apnea.Clinics and practice · 2025Article
- The Rainbow and the Umbrella of Temporomandibular Disorders-Total Antioxidant Capacity and Total Oxidant Status in Patients with Myofascial Pain with Referral.Journal of clinical medicine · 2025Article
- Clinical, psychological, and hematological factors predicting sleep bruxism in patients with temporomandibular disorders.Scientific reports · 2025Observational
- Not All Workers Experience Equal Sleep Changes: Insights from the "WorkInCovid" Project.Clocks & sleep · 2025Article
- Arginase and ceruloplasmin activity in the serum of patients with polysomnography-detected sleep bruxism.Frontiers in neurology · 2025Article
- Observational Assessment of the Effect of Sleep Bruxism on Oxyhaemoglobin Saturation:A Preliminary Study.Current health sciences journalArticle
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Authors and funding
11 authors.
Funding
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Abstract
Oxidative stress is proven to increase cardiovascular risk and to diminish healthy life expectancy. Sleep bruxism (SB) is a prevalent masticatory muscle activity during sleep characterized by heterogeneous etiology and inadequately recognized pathophysiology. Recent theories have proposed a potential association between SB and oxidative stress. The aim of the research was to compare the antioxidant status between individuals with SB in contrast to those without SB. A total of 80 adults participated in a full-night polysomnography, assessed according to the American Academy of Sleep Medicine (AASM) standards. Blood samples were subsequently drawn via venipuncture for analysis. Participants were stratified into two groups based on their bruxism episode index (BEI). Using successive receiver operating characteristic (ROC) curves, optimal cut-off values were identified, enabling the detection of correlations with moderate (BEI > 2) and severe (BEI > 4) sleep bruxism. In the investigated group of patients we observed the relationship between bruxism and the examined parameters: total antioxidant status (TAS), advanced protein products (AOPP) and thiobarbituric acid-reacting substances (TBARS). Low TAS (≤ 0.14 mM and ≤ 0. 16 mM), high AOPP (≥ 82.44 µmol/l) and high TBARS (≥ 723.03 µmol/l and ≥ 1585.45 µmol/l) serum levels result in significantly higher sleep bruxism parameters. Sleep bruxism is related to oxidative stress markers. Elevated markers of lipid and protein peroxidation may be associated with endovascular damage and cardiovascular risk in sleep bruxers, but further research is needed in this topic.
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