Evidence map›Paper›PMID 39875387›Full record

ArticleNPJ Parkinson's disease2025

Clinically probable RBD is an early predictor of malignant non-motor Parkinson's disease phenotypes.

Alfonso Enrique Martinez-Nunez, Hunter Hutchinson, Patricia Coutinho, Filipe Pereira Sarmento, Venkat Srikar Lavu, Qingqi Yuan, Jagan Mohan Reddy Dwarampudi, Aysegul Gunduz, Gregory M Pontone, Michael S Okun and 1 more

Abstract read
In one paragraph

Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  3. Article
  4. Article
  5. Clinical Associations and Possible Risk Factors for Affective Neuropsychiatric Symptoms in Older Adults With and Without Cognitive Impairment.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2026
    Article
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  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alfonso Enrique Martinez-NunezNorman Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA. Martineznuneza@ufl.edu.
Hunter HutchinsonCollege of Medicine, University of Florida, Gainesville, FL, USA.
Patricia CoutinhoNorman Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.
Filipe Pereira SarmentoNorman Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.
Venkat Srikar LavuNorman Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.
Qingqi YuanCollege of Liberal Arts and Sciences, University of Florida, Gainesville, FL, USA.
Jagan Mohan Reddy DwarampudiCollege of Liberal Arts and Sciences, University of Florida, Gainesville, FL, USA.
Aysegul GunduzNorman Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.
Gregory M PontoneNorman Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.
Michael S OkunNorman Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.
Joshua K WongNorman Fixel Institute for Neurological Disease, University of Florida, Gainesville, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-motor symptoms (NMS) in Parkinson's disease (PD) significantly impact quality of life, especially in later stages. REM sleep behavior disorder (RBD) affects approximately 42% of all PD patients and frequently precedes motor PD symptoms. RBD is linked to increased rates of depression and cognitive decline. This study explores how early RBD can predict the development of NMS profiles in patients, comparing those with and without early RBD. We identified a unique NMS profile associated with early RBD. These patients had a higher rate of cognitive impairment (M

Identifiers

PMID39875387
PMCPMC11775280

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.