Evidence map›Paper›PMID 39875380›Full record

ArticleNature communications2025

Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging.

Qiqi Liu, Zhanxia Gao, Xiangyun Zhang, Qiannan Duan, Yue Zhang, Adam C Midgley, Li Jiao, Ruming Liu, Mingsheng Zhu, Deling Kong and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Nanozyme-Driven Ferroptosis-Cuproptosis Interplay in Lung Cancer.International journal of nanomedicine · 2026
    Review
  3. Review
  4. Biomedical Applications of Nanozymes: An Enzymology Perspective.Angewandte Chemie (International ed. in English) · 2025
    Review
  5. Ferrum@albumin assembled nanoclusters inhibit NF-Acta pharmaceutica Sinica. B · 2025
    Article
  6. Multi-Dimensional Synergistic Engineering for Boosting Nanozyme Catalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Article
  8. Establishment of an ELISA for detecting oocyst-derivedFrontiers in veterinary science · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qiqi Liu *School of Medicine, Nankai University, Tianjin, 300071, China.ORCID http://orcid.org/0000-0002-8626-7683
Zhanxia Gao *School of Medicine, Nankai University, Tianjin, 300071, China.
Xiangyun Zhang *Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontier of Science Center for Cell Response, Nankai University, Tianjin, 300071, China.
Qiannan DuanKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontier of Science Center for Cell Response, Nankai University, Tianjin, 300071, China.
Yue ZhangTianjin Key Laboratory of Cellular Homeostasis and Disease, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, 300070, China.
Adam C MidgleyKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontier of Science Center for Cell Response, Nankai University, Tianjin, 300071, China.ORCID http://orcid.org/0000-0002-7622-0275
Li JiaoKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontier of Science Center for Cell Response, Nankai University, Tianjin, 300071, China.
Ruming LiuKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontier of Science Center for Cell Response, Nankai University, Tianjin, 300071, China.
Mingsheng ZhuKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontier of Science Center for Cell Response, Nankai University, Tianjin, 300071, China.
Deling KongKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontier of Science Center for Cell Response, Nankai University, Tianjin, 300071, China. kongdeling@nankai.edu.cn.ORCID http://orcid.org/0000-0002-2961-9267
Jie ZhuangSchool of Medicine, Nankai University, Tianjin, 300071, China. zhuangj@nankai.edu.cn.ORCID http://orcid.org/0009-0006-4481-0672
Xinglu HuangKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Frontier of Science Center for Cell Response, Nankai University, Tianjin, 300071, China. huangxinglu@nankai.edu.cn.ORCID http://orcid.org/0000-0002-9378-7425

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32271448National Natural Science Foundation of China (National Science Foundation of China) 32425032National Natural Science Foundation of China (National Science Foundation of China) 82072054National Natural Science Foundation of China (National Science Foundation of China) 82402481National Natural Science Foundation of China (National Science Foundation of China) 82472134
6 · The paper itself

Abstract

Nanozymes play a pivotal role in mitigating excessive oxidative stress, however, determining their specific enzyme-mimicking activities for intracellular free radical scavenging is challenging due to endo-lysosomal entrapment. In this study, we employ a genetic engineering strategy to generate ionizable ferritin nanocages (iFTn), enabling their escape from endo-lysosomes and entry into the cytoplasm. Specifically, ionizable repeated Histidine-Histidine-Glutamic acid (9H

Indexed as

Free Radical ScavengersNanostructuresSuperoxidesAnimalsCatalaseFemaleFerritinsGenetic EngineeringHumansMiceOxidative StressPolyethylene GlycolsProtein EngineeringSuperoxide DismutaseCatalaseFerritinsFree Radical ScavengersPolyethylene GlycolsSuperoxide DismutaseSuperoxides

Identifiers

PMID39875380
PMCPMC11775132

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.