ArticleNPJ Parkinson's disease2025
Morphological and functional decline of the SNc in a model of progressive parkinsonism.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- α-Synuclein pathology differentially alters T-type calcium currents in vulnerable and resilient substantia nigra dopaminergic subpopulations.bioRxiv : the preprint server for biology · 2026Article
- Alzheimer's Pathology Enhances Excitatory Synaptic Input and Integration in VTA Dopamine Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- PKC-dependent enhancement of glutamate input to VTA dopamine neurons in 3xTg-AD mice.bioRxiv : the preprint server for biology · 2025Article
- Dancing Towards Stability: The Therapeutic Potential of Argentine Tango for Balance and Mobility in Parkinson's Disease.Diseases (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The motor symptoms of Parkinson's Disease are attributed to the degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). Previous work in the MCI-Park mouse model has suggested that the loss of somatodendritic dopamine transmission predicts the development of motor deficits. In the current study, brain slices from MCI-Park mice were used to investigate dopamine signaling in the SNc prior to and through the onset of movement deficits. Electrophysiological properties were impaired by p30 and somatic volume was decreased at all time points. The D2 receptor activated potassium current evoked by quinpirole was present initially, but declined after p30. In contrast, D2-IPSCs were absent at all time points. The decrease in GPCR-mediated inhibition was met with increased spontaneous GABA
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