ArticleNature communications2025
Platelet-white cell ratio is more strongly associated with mortality than other common risk ratios derived from complete blood counts.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Changes in leukocytes and CRP in different treatments of major depression.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Evaluation of the platelet-to-white-cell ratio (PWR) as predictor of long-term all-cause mortality in patients with acute myocardial infarction.Scientific reports · 2026Article
- [Clinical characteristics and gender differences in Wagner grade 4-5 diabetic foot patients with variable severity of lower extremity atherosclerotic occlusive disease].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Association of a Composite Inflammatory Score with Stroke Prevalence: A Cross-Sectional Study.Life (Basel, Switzerland) · 2026Article
- A community‑based study of platelet‑to‑white blood cell ratio and new‑onset type 2 diabetes in older adults.BMC endocrine disorders · 2026Article
- Association between platelet-white cell ratio and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective cohort study.BMC cardiovascular disorders · 2026Article
- Correlations of Glycaemic Index and Estimated Whole Blood Viscosity with Blood Cell Indices in Diabetes Mellitus Management: A Clinical Laboratory Medicine Observational Cohort Study.Journal of clinical medicine · 2026Article
- Predictive Value of Platelet-Based Indexes for Mortality in Sepsis.Biomedicines · 2026Article
- Prognostic value of platelet-to-white blood cell ratio in critically ill patients with non-traumatic subarachnoid hemorrhage: a machine learning-driven study of the public database and the hospital information system.Frontiers in neurology · 2026Observational
- Predictive value of gut metabolites combined with neutrophil to platelet ratio for clinical functional outcome in acute ischemic stroke treated with endovascular therapy.Frontiers in nutrition · 2026Article
- Mean platelet volume is a predictor for abscess formation in patients with epididymitis.Translational andrology and urology · 2025Article
- Hematologic Ratios in Donkeys: Reference Intervals and Response to Experimentally Induced Endotoxemia.Animals : an open access journal from MDPI · 2025Article
- Assessment of Common Hematologic Parameters and Novel Hematologic Ratios for Predicting Piroplasmosis Infection in Horses.Animals : an open access journal from MDPI · 2025Article
- Transformer-based artificial intelligence on single-cell clinical data for homeostatic mechanism inference and rational biomarker discovery.medRxiv : the preprint server for health sciences · 2025Article
- Platelet-to-white blood cell ratio as a predictor of postoperative outcomes in acute type A aortic dissection: a single-center retrospective analysis.Frontiers in cardiovascular medicine · 2025Article
- Development and validation of a machine learning model for in-hospital mortality prediction in children under 5 years with heart failure.Frontiers in pediatrics · 2025Article
- Nomogram-based prediction of hemorrhagic transformation risk integrating platelet-to-white blood cell ratio in patients with acute ischemic stroke after intravenous thrombolysis.Frontiers in neurologyArticle
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Authors and funding
4 authors.
Funding
Abstract
Complete blood count indices and their ratios are associated with adverse clinical outcomes for many acute illnesses, but the mechanisms generating these associations are not fully understood. Recent identification of a consistent pattern of white blood cell and platelet count co-regulation during acute inflammatory recovery provides a potentially unifying explanation. Here we show that the platelet-to-white-cell ratio, which was selected based on this conserved recovery pattern, is more strongly associated with mortality than other blood count markers and ratios in four important illnesses involving acute inflammation: COVID-19, acute heart failure, myocardial infarction, and stroke. Patients recovering well from these acute illnesses tend to follow a joint white cell and platelet trajectory that can be reduced to this one-dimensional ratio. The platelet-to-white-cell ratio's association with prognosis is consistent with recently identified inflammatory dynamics and may provide a convenient and interpretable summary of patient inflammatory state.
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