Evidence map›Paper›PMID 39875316›Full record

ArticleHuman vaccines & immunotherapeutics2025

Vaccine effectiveness against influenza-associated hospitalizations in adults with liver disease, 2015-2020: US Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN).

Po-Han Huang, Mary Patricia Nowalk, Richard K Zimmerman, Samantha M Olson, H Keipp Talbot, Yuwei Zhu, Manjusha Gaglani, Kempapura Murthy, Arnold S Monto, Emily T Martin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Po-Han HuangDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Mary Patricia NowalkDepartment of Family Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Richard K ZimmermanDepartment of Family Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Samantha M OlsonInfluenza Division, Centers for Disease Control and Prevention, Atlanta, GA, USA.
H Keipp TalbotDivision of Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
Yuwei ZhuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Manjusha GaglaniDepartment of Research Analytics and Development, Baylor Scott & White Health, Temple, TX, USA.
Kempapura MurthyDepartment of Research Analytics and Development, Baylor Scott & White Health, Temple, TX, USA.
Arnold S MontoCenter for Respiratory Virus Research and Response, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Emily T MartinCenter for Respiratory Virus Research and Response, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Fernanda P SilveiraDepartment of Medicine, Division of Infectious Diseases, University of Pittsburgh, Pittsburgh, PA, USA.
G K BalasubramaniDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
EPA EP-C-15-002NCATS NIH HHS UL1 TR001857NCATS NIH HHS UL1 TR002243NCIRD CDC HHS U01 IP000972
6 · The paper itself

Abstract

Influenza causes 100,000-710,000 hospitalizations annually in the U.S. Patients with liver disease are at higher risk of severe outcomes following influenza infection. This study evaluated influenza vaccine effectiveness (VE) against influenza-associated hospitalization among adults with liver disease. Data from the U.S. Hospitalized Adult Influenza Vaccine Effectiveness Network (HAIVEN), a test-negative case-control study, from 2015 to 2020 were used to estimate VE among adults ≥18 years admitted for acute respiratory illness. VE was calculated as (1-adjusted odds ratio)*100%, comparing the odds of vaccine receipt between laboratory-confirmed influenza cases and test-negative controls using multiple logistic regression with inverse probability of treatment weighting (IPTW). In total, 1,622 (12.8%) of 12,704 adults had ≥1 liver disease(s). Compared with those without liver disease, adults with liver disease were more likely to be admitted to the intensive care unit (15.7% vs 12.8%,

Indexed as

HospitalizationInfluenza, HumanInfluenza VaccinesLiver DiseasesVaccine EfficacyAdolescentAdultAgedFemaleHumansMaleMiddle AgedPatient AcuityRisk FactorsTime FactorsTreatment OutcomeInfluenza VaccinesimmunocompromisedInfluenzaliver diseasevaccinevaccine effectiveness

Identifiers

PMID39875316
PMCPMC11776484

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.