Evidence map›Paper›PMID 39875174›Full record

ArticleRNA (New York, N.Y.)2025

Role of the sarcin-ricin loop of 23S rRNA in biogenesis of the 50S ribosomal subunit.

Sepideh Fakhretaha Aval, Amal Seffouh, Kyung-Mee Moon, Leonard J Foster, Joaquin Ortega, Kurt Fredrick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sepideh Fakhretaha AvalOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA.
Amal SeffouhDepartment of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 0C7, Canada.
Kyung-Mee MoonDepartment of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada.
Leonard J FosterDepartment of Biochemistry and Molecular Biology, Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T1Z4, Canada.
Joaquin OrtegaDepartment of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 0C7, Canada.ORCID 0000-0002-9423-3344
Kurt FredrickOhio State Biochemistry Program, The Ohio State University, Columbus, Ohio 43210, USA fredrick.5@osu.edu.

Funding

Molecular analysis of accurate ribosomal translocationR01GM072528 · NIGMS · OHIO STATE UNIVERSITY · PI Kurt L Fredrick · 2005 to 2026
$5.8M
NIGMS NIH HHS R01 GM072528
6 · The paper itself

Abstract

The sarcin-ricin loop (SRL) is one of the most conserved segments of ribosomal RNA (rRNA). Translational GTPases (trGTPases), such as EF-G, EF-Tu, and IF2, form contacts with the SRL that are critical for GTP hydrolysis and factor function. Previous studies showed that expression of 23S rRNA lacking the SRL confers a dominant lethal phenotype in

Indexed as

Ribosome Subunits, Large, BacterialRNA, Ribosomal, 23SCryoelectron MicroscopyEscherichia coliEscherichia coli ProteinsGTP PhosphohydrolasesNucleic Acid ConformationPeptidyl TransferasesProtein BiosynthesisEscherichia coli ProteinsGTP PhosphohydrolasesPeptidyl TransferasesRNA, Ribosomal, 23SassemblyEF-TuGTPaseIF2ObgEtranslation

Identifiers

PMID39875174
PMCPMC11912913

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.