Evidence map›Paper›PMID 39875084›Full record

ArticleBrain research2025

Elevated plasma Tau-PT217 linked to decreased hippocampal functional connectivity in patients with knee osteoarthritis.

Ya Wen, Mattia Cannistra, Valeria Sacca, Linting Ma, Liang Feng, Zhongcong Xie, Jian Kong

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Article in Brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ya WenDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Mattia CannistraDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Valeria SaccaDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Linting MaDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Liang FengGeriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Zhongcong XieGeriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Jian KongDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: jkong2@mgh.harvard.edu.

Funding

Modulation effects of imagined acupuncture and no touch placebo acupunctureR33AT009310 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KONG, JIAN · 2018 to 2021
$2.7M
NCCIH NIH HHS R33 AT009310
6 · The paper itself

Abstract

backgroundOsteoarthritis is associated with a higher risk of developing dementia, though the underlying biological mechanisms have remained unclear. Recent studies suggest that blood phosphorylated tau proteins, particularly Tau-PT217, are sensitive biomarkers capable of detecting cognitive decline in its early stages, making it useful for early diagnosis of Alzheimer's disease and other forms of cognitive impairment.

methodsIn this study, we investigated the plasma phosphorylated tau protein levels (Tau-PT217 and Tau-PT181), hippocampus functional connectivity, and cognitive function in people with knee osteoarthritis compared to age and gender matched pain-free controls.

resultsWe found that knee osteoarthritis was associated with increased plasma levels of Tau-PT217 (but not Tau-PT181), and that the Tau-PT217 is also correlated with reduced hippocampal functional connectivity with middle cingulate cortex. Our findings suggest a potential biological correlation between knee osteoarthritis and an elevated risk of dementia, contributing valuable insights that may guide the formulation of early intervention and preventative strategies to mitigate dementia in individuals with knee osteoarthritis.

Indexed as

HippocampusOsteoarthritis, Kneetau ProteinsAgedBiomarkersCognitive DysfunctionFemaleGyrus CinguliHumansMagnetic Resonance ImagingMaleMiddle AgedNeural PathwaysPhosphorylationBiomarkersMAPT protein, humantau Proteins

Identifiers

PMID39875084
PMCPMC11848939

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.