ArticleNeuron2025
Topography of putative bi-directional interaction between hippocampal sharp-wave ripples and neocortical slow oscillations.
Article in Neuron, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Ictal Epileptogenic Network Differences in Posterior Cingulate Epilepsy Subtypes Based on SEEG.CNS neuroscience & therapeutics · 2026Article
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- Sleep lowers waking theta frequency in the rat hippocampus.Cell reports · 2026Article
- Article
- Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state.Neuron · 2026Article
- Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- Burst firing creates an attractor in synaptic weight dynamics.PLoS computational biology · 2026Article
- Hippocampal synchrony dynamically gates cortical connectivity across brain states.Scientific reports · 2026Article
- Subspace communication in the hippocampal-retrosplenial axis.bioRxiv : the preprint server for biology · 2026Article
- Long-Term Memory Updating Parallels Altered Awake and Sleep Hippocampal Replays.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Time, space, memory and brain-body rhythms.Nature reviews. Neuroscience · 2026Review
- Systems memory consolidation during sleep: oscillations, neuromodulators, and synaptic remodeling.BMB reports · 2025Review
- Brain sources composing irregular field potentials have unique temporal signatures.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes.Frontiers in behavioral neuroscience · 2025Article
- High-frequency oscillations and sleep spindles in epilepsy: from mechanisms to modeling.Frontiers in neurologyReview
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Authors and funding
8 authors.
Funding
Abstract
Systems consolidation relies on coordination between hippocampal sharp-wave ripples (SWRs) and neocortical UP/DOWN states during sleep. However, whether this coupling exists across the neocortex and the mechanisms enabling it remains unknown. By combining electrophysiology in mouse hippocampus (HPC) and retrosplenial cortex (RSC) with wide-field imaging of the dorsal neocortex, we found spatially and temporally precise bi-directional hippocampo-neocortical interaction. HPC multi-unit activity and SWR probability were correlated with UP/DOWN states in the default mode network (DMN), with the highest modulation by the RSC in deep sleep. Further, some SWRs were preceded by the high rebound excitation accompanying DMN DOWN → UP transitions, whereas large-amplitude SWRs were often followed by DOWN states originating in the RSC. We explain these electrophysiological results with a model in which the HPC and RSC are weakly coupled excitable systems capable of bi-directional perturbation and suggest that the RSC may act as a gateway through which SWRs can perturb downstream cortical regions via cortico-cortical propagation of DOWN states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.