Evidence map›Paper›PMID 39874948›Full record

ArticleCell reports methods2025

Selective activation of mesoscale functional circuits via multichannel infrared stimulation of cortical columns in ultra-high-field 7T MRI.

Feiyan Tian, Yipeng Liu, Meixuan Chen, Kenneth Edward Schriver, Anna Wang Roe

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PubMed Full text at PMC Publisher
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Article in Cell reports methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Feiyan TianDepartment of Neurosurgery of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China; Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou 310029, China; National Key Laboratory of Brain and Computer Intelligence, Zhejiang University, Hangzhou 310058, China; Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China.
Yipeng LiuInterdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou 310029, China.
Meixuan ChenInterdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou 310029, China.
Kenneth Edward SchriverInterdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou 310029, China; MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310012, China.
Anna Wang RoeDepartment of Neurosurgery of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China; Interdisciplinary Institute of Neuroscience and Technology, School of Medicine, Zhejiang University, Hangzhou 310029, China; National Key Laboratory of Brain and Computer Intelligence, Zhejiang University, Hangzhou 310058, China; Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China; MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310012, China. Electronic address: annawang@zju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To restore vision in the blind, advances in visual cortical prosthetics (VCPs) have offered high-channel-count electrical interfaces. Here, we design a 100-fiber optical bundle interface apposed to known feature-specific (color, shape, motion, and depth) functional columns that populate the visual cortex in humans, primates, and cats. Based on a non-viral optical stimulation method (INS, infrared neural stimulation; 1,875 nm), it can deliver dynamic patterns of stimulation, is non-penetrating and non-damaging to tissue, and is movable and removable. In addition, its magnetic resonance (MR) compatibility (INS-fMRI) permits systematic mapping of brain-wide circuits. In the MRI, we illustrate (1) the single-point activation of functionally specific networks, (2) shifting cortical networks activated via shifting points of stimulation, and (3) "moving dot" stimulation-evoked activation of higher-order motion-selective areas. We suggest that, by mimicking patterns of columnar activation normally activated by visual stimuli, a columnar VCP opens doors for the planned activation of feature-specific circuits and their associated visual percepts.

Indexed as

Infrared RaysMagnetic Resonance ImagingVisual CortexAnimalsBrain MappingCatsHumansMalePhotic StimulationVisual Prosthesisbrain-machine interfacecortical columnCP: Neuroscienceinfrared neural stimulationINS-fMRImultifiber optical bundleultra-high-field fMRIvisual cortical prosthetics

Identifiers

PMID39874948
PMCPMC11840946

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.