Evidence map›Paper›PMID 39874807›Full record

ArticleInternational journal of surgery case reports2025

Successful laparoscopic cytoreductive surgery for multiple (three) advanced recurrences of AGCT in a young woman. A case report.

Antonio Macciò, Valerio Vallerino, Gabriele Sole, Sonia Nemolato, Emanuela Giglio, Clelia Madeddu

Abstract readCase Reports
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Article in International journal of surgery case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Antonio MacciòDepartment of Obstetrics and Gynecology, ARNAS G. Brotzu, via Jenner, 09100 Cagliari, Italy; Department of Surgical Sciences, University of Cagliari, SS 554, km 4,500, 09042 Monserrato, Italy. Electronic address: antoniomaccio56@gmail.com.
Valerio VallerinoDepartment of Obstetrics and Gynecology, ARNAS G. Brotzu, via Jenner, 09100 Cagliari, Italy.
Gabriele SoleDepartment of Obstetrics and Gynecology, ARNAS G. Brotzu, via Jenner, 09100 Cagliari, Italy.
Sonia NemolatoUnit of Anatomic Pathology, ARNAS G. Brotzu, via Jenner, 09100 Cagliari, Italy.
Emanuela GiglioDepartment of Obstetrics and Gynecology, ARNAS G. Brotzu, via Jenner, 09100 Cagliari, Italy.
Clelia MadedduDepartment of Medical Sciences and Public Health, University of Cagliari, SS 554, km 4,500, 09042 Monserrato, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and importanceDebulking surgery is the main approach for recurrent adult granulosa cell tumors (AGCTs), but the effectiveness of laparoscopic extensive cytoreduction in advanced cases and its impact on quality of life (QoL) remains unclear. CASE PRESENTATION: A 34-year-old woman, who had a right adnexectomy for AGCT in 2020, was referred with an 8-month history of a large left ovarian cyst and amenorrhea. Preoperative evaluations indicated a recurrence 18 months post-diagnosis. After discussing her career as a photo model, which required optimal aesthetic outcomes, we opted for total laparoscopic surgery, including radical type A hysterectomy, left salpingo-oophorectomy, pelvic peritonectomy, total mesorectal excision, total omentectomy, and pelvic and lumbo-aortic lymphadenectomy. Pathology confirmed stage 3C recurrent AGCT. After discussions, the patient declined adjuvant chemotherapy and received progestins with close follow-up. Fourteen months later, a positron emission tomography (PET) showed high metabolic activity in the left iliac fossa and right pelvis, confirmed by magnetic resonance as pelvic lymph node recurrence and small intestine involvement. She underwent laparoscopic cytoreductive surgery, including peritonectomy, lymph node metastases removal, and intestinal resection. She recovered with excellent aesthetic results and QoL. She completed six cycles of adjuvant cisplatin (80 mg/m2). Ten months later, following a suspected PET, a diagnostic/operative laparoscopy revealed a miliary peritoneal carcinosis, particularly in Morrison's space. CLINICAL DISCUSSION: Repeated laparoscopic extensive surgery for recurrent advanced AGCT yielded excellent aesthetic outcomes and effective cytoreduction.

conclusionThis case supports the safety and efficacy of minimally invasive techniques, emphasizing their role in preserving QoL and body image.

Indexed as

Advanced ovarian cancerLaparoscopyMinimally invasive surgeryOvarian granulosa cell tumorsQuality of lifeTumor recurrence

Identifiers

PMID39874807
PMCPMC11808675

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