Evidence map›Paper›PMID 39874747›Full record

ReviewClinical oncology (Royal College of Radiologists (Great Britain))2025

Sex-Based Bias in Artificial Intelligence-Based Segmentation Models in Clinical Oncology.

F X Doo, W G Naranjo, T Kapouranis, M Thor, M Chao, X Yang, D C Marshall

Abstract readReview
In one paragraph

Review in Clinical oncology (Royal College of Radiologists (Great Britain)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

F X DooUniversity of Maryland Medical Intelligent Imaging (UM2ii) Center, Department of Radiology and Nuclear Medicine, University of Maryland, Baltimore, MD, USA; University of Maryland-Institute for Health Computing (UM-IHC), University of Maryland, North Bethesda, MD, USA.
W G NaranjoDepartment of Medical Physics, Columbia University, New York, New York, USA; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
T KapouranisDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
M ThorMemorial Sloan Kettering Cancer Center, New York, New York, USA.
M ChaoDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
X YangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA.
D C MarshallDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA. Electronic address: deborah.marshall@mountsinai.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Novel Functional Anatomic and Biomarker Indices of Radiation-Induced Female Sexual Toxicities in a Multi-Center CohortDP5OD031876 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARSHALL, DEBORAH CATHERINE · 2021 to 2025
$2.1M
NCI NIH HHS P30 CA008748NIH HHS DP5 OD031876
6 · The paper itself

Abstract

Artificial intelligence (AI) advancements have accelerated applications of imaging in clinical oncology, especially in revolutionizing the safe and accurate delivery of state-of-the-art imaging-guided radiotherapy techniques. However, concerns are growing over the potential for sex-related bias and the omission of female-specific data in multi-organ segmentation algorithm development pipelines. Opportunities exist for addressing sex-specific data as a source of bias, and improving sex inclusion to adequately inform the development of AI-based technologies to ensure their fairness, generalizability and equitable distribution. The goal of this review is to discuss the importance of biological sex for AI-based multi-organ image segmentation in routine clinical and radiation oncology; sources of sex-based bias in data generation, model building and implementation and recommendations to ensure AI equity in this rapidly evolving domain.

Indexed as

Artificial IntelligenceMedical OncologySexismAnimalsFemaleHumansMaleSex FactorsAlgorithmic biasartificial intelligencedeep learningmedical image segmentationradiotherapysex bias

Identifiers

PMID39874747
PMCPMC11850178

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.