Evidence map›Paper›PMID 39874717›Full record

ArticleClinical nutrition (Edinburgh, Scotland)2025

Brown adipose tissue is associated with reduced weight loss and risk of cancer cachexia: A retrospective cohort study.

Grigorios Panagiotou, Demsina Babazadeh, Dario F Mazza, Soheila Azghadi, Joseph M Cawood, Aaron S Rosenberg, Fumiaki Imamura, Nita G Forouhi, Abhijit J Chaudhari, Yasser G Abdelhafez and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical nutrition (Edinburgh, Scotland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Physical Activity, Exerkines, and Their Role in Cancer Cachexia.International journal of molecular sciences · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Grigorios PanagiotouMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Demsina BabazadehDepartment of Nutrition, University of California Davis, Davis, CA, USA.
Dario F MazzaDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Soheila AzghadiDivision of Hematology and Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.
Joseph M CawoodData Center of Excellence, Innovation Technology, University of California Davis, Sacramento, CA, USA.
Aaron S RosenbergMalignant Hematology, Cellular Therapy & Transplantation, University of California Davis, Sacramento, CA, USA.
Fumiaki ImamuraMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Nita G ForouhiMRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Abhijit J ChaudhariDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Yasser G AbdelhafezDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Ramsey D BadawiDepartment of Radiology, University of California Davis, Sacramento, CA, USA.
Maria ChondronikolaMetabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK; Department of Nutrition, University of California Davis, Davis, CA, USA; Department of Radiology, University of California Davis, Sacramento, CA, USA; Department of Nutritional Sciences and Dietetics, Harokopio University of Athens, Greece. Electronic address: mc2425@cam.ac.uk.

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
Total-body PET for assessing myofascial painR61AT012187 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAUDHARI, ABHIJIT J, NARDO, LORENZO · 2022 to 2022
$2.1M
Total-Body PET/CT for assessing Rheumatoid Arthritis Disease Activity and Treatment ResponseR01AR076088 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHAUDHARI, ABHIJIT J · 2019 to 2021
$617k
Characterization of Spinal Pathology in Axial Psoriatic ArthritisR01AR085314 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Abhijit J Chaudhari, SIBA P RAYCHAUDHURI · 2025 to 2026
$434k
Medical Research Council MC_UU_00006/3NCCIH NIH HHS R61 AT012187NCI NIH HHS P30 CA093373NIAMS NIH HHS R01 AR076088NIAMS NIH HHS R01 AR085314Wellcome Trust 208363
6 · The paper itself

Abstract

BACKGROUND &

aimsBrown adipose tissue (BAT) has been mainly investigated as a potential target against cardiometabolic disease, but it has also been linked to cancer-related outcomes. Although preclinical data support that BAT and the thermogenic adipocytes in white adipose tissue may play an adverse role in the pathogenesis of cancer cachexia, results from studies in patients have reported inconsistent results. The purpose of this study was to examine the interrelationship between presence of detectable BAT, changes in body weight, and cachexia in patients with cancer. We hypothesized that evidence of BAT at cancer diagnosis would be associated with greater weight loss and risk of cancer cachexia up to a year after cancer diagnosis.

methodsWe conducted a retrospective cohort study in treatment-naïve patients with detectable BAT (BAT+, n = 57) and without evidence of BAT (BAT-, n = 73) on 2-deoxy-2-[

resultsThe BAT+ group experienced a lower magnitude of weight loss compared with the BAT- group during the 1-year follow-up (p = 0.014 for interaction between BAT status and time). The risk for cancer cachexia was 44 % lower in the BAT+ than the BAT- group, adjusted for age, sex, outdoor temperature on the day of the

conclusionContrary to our original hypothesis, evidence of BAT assessed by

Indexed as

Adipose Tissue, BrownCachexiaNeoplasmsWeight LossAgedFemaleHumansMaleMiddle AgedPositron Emission Tomography Computed TomographyRetrospective StudiesRisk FactorsBrown adipose tissueCachexiaCancerMuscleObesity

Identifiers

PMID39874717
PMCPMC12105605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.