Evidence map›Paper›PMID 39874479›Full record

ArticleThe journal of physical chemistry. B2025

Directed Evolution's Selective Use of Quantum Tunneling in Designed Enzymes─A Combined Theoretical and Experimental Study.

Kseniia Korchagina, Sree Ganesh Balasubramani, Jordan Berreur, Emilie F Gerard, Linus O Johannissen, Anthony P Green, Sam Hay, Steven D Schwartz

Abstract read
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In one paragraph

Article in The journal of physical chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kseniia KorchaginaDepartment of Chemistry and Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, Arizona 85721, United States.
Sree Ganesh BalasubramaniQuantitative Biosciences Institute, University of California, 1700 Fourth Street, San Francisco, California 94158, United States.
Jordan BerreurManchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.ORCID 0000-0001-7713-438X
Emilie F GerardManchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Linus O JohannissenManchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Anthony P GreenManchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.ORCID 0000-0003-0454-1798
Sam HayManchester Institute of Biotechnology and Department of Chemistry, The University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.ORCID 0000-0003-3274-0938
Steven D SchwartzDepartment of Chemistry and Biochemistry, University of Arizona, 1306 East University Boulevard, Tucson, Arizona 85721, United States.ORCID 0000-0002-0308-1059

Funding

Protein dynamics from femtoseconds to milliseconds as crafted by natural and laboratory evolution: towards enzyme designR35GM145213 · NIGMS · UNIVERSITY OF ARIZONA · PI STEVEN D SCHWARTZ · 2022 to 2026
$2.1M
NIGMS NIH HHS R35 GM145213
6 · The paper itself

Abstract

Natural enzymes are powerful catalysts, reducing the apparent activation energy for reactions and enabling chemistry to proceed as much as 10

Identifiers

PMID39874479
PMCPMC11804154

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.