Evidence map›Paper›PMID 39874221›Full record

ArticleEpigenetics2025

Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC).

Shafiq Shaikh, Xia Zhao, Ryan T Wagner, Xiaoyu Pan, Ryan A Hlady, Liguo Wang, Thai H Ho, Keith D Robertson

Abstract read
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shafiq ShaikhDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Xia ZhaoDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Ryan T WagnerDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Xiaoyu PanDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Ryan A HladyDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Liguo WangDivision of Computational Biology, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Thai H HoDivision of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, USA.
Keith D RobertsonDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-7508-3328

Funding

Synthetic Lethal Targeting of SETD2 in Renal Cell CarcinomaR01CA271503 · NCI · MAYO CLINIC ROCHESTER · PI Thai Huu Ho, Keith D Robertson · 2023 to 2026
$2.1M
RNA methylation as a novel effector of SETD2 in kidney cancerR21CA283539 · NCI · MAYO CLINIC ROCHESTER · PI ROBERTSON, KEITH D · 2024 to 2025
$415k
NCI NIH HHS R01 CA271503NCI NIH HHS R21 CA283539
6 · The paper itself

Abstract

RNA N6-methyladenosine (m6A) plays diverse roles in RNA metabolism and its deregulation contributes to tumor initiation and progression. Clear cell renal cell carcinoma (ccRCC) is characterized by near ubiquitous loss of

Indexed as

AdenosineCarcinoma, Renal CellHistone-Lysine N-MethyltransferaseHistonesKidney NeoplasmsCell Line, TumorGene Expression Regulation, NeoplasticHistone CodeHumansMethylationAdenosineHistone-Lysine N-MethyltransferaseHistonesN-methyladenosineSETD2 protein, humanccRCCH3K27acH3K36me3METTL3N6-methyladenosine (m6A)renal cell cancerSETD2STM2457

Identifiers

PMID39874221
PMCPMC11776469

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.