ArticleAsian Pacific journal of cancer prevention : APJCP2025
Interleukin-17A and Interleukin-17F Gene Polymorphisms in Egyptian Patients with Chronic Hepatitis C and Hepatocellular Carcinoma.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Genomic profiling of AKT1 and NRAS mutations using NGS in Egyptian hepatocellular carcinoma.Discover oncology · 2025Article
- Epidermal Growth Factor (EGF rs4444903) Gene Polymorphism and Risk of HCC in Egyptian HCV Cirrhotic Patients.Asian Pacific journal of cancer prevention : APJCP · 2025Article
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4 authors.
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Abstract
objectiveInterleukin IL-17A and IL-17F are critical cytokines involved in inflammatory processes. Genetic variations in IL-17A and IL-17F might be linked to chronic hepatitis C (CHC) and an increased risk of hepatocellular carcinoma (HCC), a cancer associated with long-term inflammation. This study aims to examine the relationship between specific polymorphisms in IL-17A (rs2275913) and IL-17F (rs763780) and their association with HCV-related HCC in an Egyptian population.
methodsAuthors conducted a case-control study involving 52 patients with chronic hepatitis C, 49 patients with HCV-related HCC, and 51 healthy controls. The study assessed the connection between the IL-17A rs2275913 and IL-17F rs763780 polymorphisms and chronic hepatitis C patients. Genotyping was performed using real-time PCR with TaqMan MGB-probe allelic discrimination.
resultsNo significant differences in genotype and allele frequencies for IL-17A rs2275913 and IL-17F rs763780 were observed between CHC or HCC patients and control subjects. However, significant associations were found indicating an increased risk of HCC linked to CHC: the GG genotype of IL-17A rs2275913 in a recessive model (P = 0.0129); and CT and CT + CC genotypes as well as the C allele of IL-17F rs763780 (P = 0.0038, P = 0.0055 and P = 0.0277, respectively).
conclusionThe study identifies a significant association between IL-17F rs763780 polymorphisms and a higher risk of HCC in Egyptian patients with chronic hepatitis C. No significant correlation was found between the IL-17A rs2275913 polymorphism and either chronic hepatitis C or HCC.
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