ArticleAsian Pacific journal of cancer prevention : APJCP2025
Immunohistochemical Expression of VEGF and Microvessel Density (CD 34) in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Original Research.
Article in Asian Pacific journal of cancer prevention : APJCP, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Prognostic Significance of CD105-Assessed Angiogenesis in Relation to Survival and Clinicopathological Features of Oral Squamous Cell Carcinoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Article
- Differential Diagnosis of Oral Salivary Gland Carcinoma and Squamous Cell Carcinoma Using Quantitative Dynamic Contrast-Enhanced MRI.Journal of clinical medicine · 2026Article
- Current and Emerging Protein Biomarkers for the Diagnosis and Prognosis of Head and Neck Cancer.Genes · 2025Review
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6 authors.
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Abstract
backgroundAngiogenesis, the formation of new blood vessels from preexisting ones via capillary sprouting, is a crucial process in tumor growth and metastasis. As a tumor's angiogenic capacity increases, its microvasculature, measured by micro vessel density (MVD), also increases. This study aims to evaluate the expression of Vascular Endothelial Growth Factor (VEGF) and CD34 in oral epithelial dysplasia and oral squamous cell carcinoma through immunohistochemical methods.
methodsThe study analyzed a total of 40 formalin-fixed, paraffin-embedded tissue samples. These included 10 cases of normal buccal mucosa, 15 cases of oral epithelial dysplasia, and 15 cases of oral squamous cell carcinoma. Immunohistochemical staining was performed using monoclonal anti-VEGF and anti-CD34 antibodies. The intensity and area of staining for VEGF were assessed, and the mean MVD was calculated. Statistical analysis was conducted using Pearson's chi-square test and one-way ANOVA.
resultsThe expression of VEGF and MVD (indicated by CD34 staining) were significantly higher in oral squamous cell carcinoma compared to oral epithelial dysplasia and normal buccal mucosa.
conclusionAs tumors grow, angiogenesis increases proportionally with tumor volume and disease progression, contributing to tumorigenesis. VEGF serves as a critical mitogen for tumor vascularization, and MVD can be a useful indicator of disease progression.
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