Evidence map›Paper›PMID 39873950›Full record

ArticleNeurogastroenterology and motility2025

Utility of a

Revati Varma, Catherine E Williams, Ethan S McClain, Kent R Bailey, Tamas Ordog, Adil E Bharucha

Abstract read
In one paragraph

Article in Neurogastroenterology and motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Revati VarmaDivision of Gastroenterology and Hepatology, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Catherine E WilliamsCairn Diagnostics, Brentwood, Tennessee, USA.
Ethan S McClainCairn Diagnostics, Brentwood, Tennessee, USA.
Kent R BaileyDivision of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, Minnesota, USA.
Tamas OrdogDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Adil E BharuchaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.ORCID https://orcid.org/0000-0002-7644-0390

Funding

Epigenetic dysregulation in diabetic enteric neuropathyR01DK126827 · NIDDK · MAYO CLINIC ROCHESTER · PI ORDOG, TAMAS · 2021 to 2024
$2.1M
Single-cell epigenomics and transcriptomics of diabetic gastroparesis in humansR01DK131455 · NIDDK · MAYO CLINIC ROCHESTER · PI BHARUCHA, ADIL E., ORDOG, TAMAS · 2021 to 2025
$2.0M
NIDDK NIH HHS R01 DK126827NIDDK NIH HHS R01 DK 131455NIDDK NIH HHS R01 DK131455
6 · The paper itself

Abstract

backgroundThe carbon-13 spirulina gastric emptying breath test (GEBT) is approved to identify delayed, but not accelerated, gastric emptying (GE). We compared the utility of the GEBT to scintigraphy for diagnosing abnormal GE in patients with diabetes mellitus.

methodsTwenty-eight patients with diabetes ate a 230-kcal test meal labeled with technetium 99 m and KEY

resultsScintigraphy revealed normal, delayed, and accelerated GE, respectively, in 17 (30%), 29 (52%), and 10 (18%) test results. GE T½ values measured with scintigraphy and GEBT were highly concordant within individuals; the intraindividual reproducibility was 34% (scintigraphy) and 15% (GEBT). Compared to current criteria, the kPCD150 (150 min) and kPCD180 values provided equally sensitive (90%) and more specific (81% vs. 67%) approach for distinguishing between delayed versus normal/accelerated GE. A new metric (kPCD60-kPCD15 min) was 90% sensitive and 83% specific for distinguishing between accelerated versus normal/delayed GE. These findings were used to create nomograms and an algorithm for interpreting GEBT results. CONCLUSIONS AND INFERENCES: Among patients with poorly controlled diabetes, the

Indexed as

Diabetes MellitusGastric EmptyingSpirulinaAdultAgedBreath TestsCarbon IsotopesFemaleHumansMaleMiddle AgedRadionuclide ImagingReproducibility of ResultsCarbon-13Carbon Isotopesbreath testdiabetesgastric emptyinggastroparesisscintigraphy

Identifiers

PMID39873950
PMCPMC11996606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.