Evidence map›Paper›PMID 39873909›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

The role of circular RNAs in autoimmune diseases: Potential diagnostic biomarkers and therapeutic targets.

Xin'ai Li, Junhui Wang, Peng Wang, Shuo Qi, Jeremiah Amalraj, Jingwei Zhou, Zhiguo Ding

Abstract readReview
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. The role of circular RNAs in autoimmune diseases: Potential diagnostic biomarkers and therapeutic targets.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xin'ai LiDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.ORCID https://orcid.org/0000-0003-3407-908X
Junhui WangThyropathy Hospital, Sun Simiao Hospital, Beijing University of Chinese Medicine, Tongchuan, China.ORCID https://orcid.org/0000-0003-0892-9909
Peng WangThe Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.ORCID https://orcid.org/0009-0003-6782-5939
Shuo QiDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.ORCID https://orcid.org/0000-0001-7559-4606
Jeremiah AmalrajHuman Biology Program, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0009-0008-3171-6673
Jingwei ZhouThe 1st Ward, Department of Nephrology and Endocrinology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.ORCID https://orcid.org/0000-0002-2377-0409
Zhiguo DingDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.ORCID https://orcid.org/0000-0003-3955-9779

Funding

Science and Technology Department of Shanxi Province, China 2022KXJ 019Science and Technology Department of Shanxi Province, China 2023 56Shanxi Central Administration Bureau, Shanxi Province, China 2022 005
6 · The paper itself

Abstract

With the emergence of high-quality sequencing technologies, further research on transcriptomes has become possible. Circular RNA (circRNA), a novel type of endogenous RNA molecule with a covalently closed circular structure through "back-splicing," is reported to be widely present in eukaryotic cells and participates mainly in regulating gene and protein expression in various ways. It is becoming a research hotspot in the non-coding RNA field. CircRNA shows close relation to several varieties of autoimmune diseases (AIDs) in both the physiological and pathological level and could potentially be used clinically in terms of diagnosis and treatment. Here, we focus on reviewing the importance of circRNA in various AIDs, with the aim of establishing new biomarkers and providing novel insights into understanding the role and functions of circRNA in AIDs. Specific signaling pathways of how circular RNAs are regulated in AIDs will also be illustrated in this review.

Indexed as

Autoimmune DiseasesRNARNA, CircularAnimalsBiomarkersHumansBiomarkersRNARNA, Circularautoimmune diseasesbiomarkercircular RNAdiagnosistreatment

Identifiers

PMID39873909
PMCPMC11774230

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.