ArticleMedical physics2025
MR imaging of proton beam-induced oxygen depletion.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- MR imaging of proton beam-induced oxygen depletion.Medical physics · 2025Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have shown that in-beam magnetic resonance imaging (MRI) can be used to visualize a proton beam during the irradiation of liquid-filled phantoms. The beam energy- and current-dependent local image contrast observed in water was identified to be predominantly caused by beam-induced buoyant convection and associated flow effects. Besides this flow dependency, the MR signal change was found to be characterized by a change in the PURPOSE: The underlying radiochemical cause of the observed local beam-induced change in the
methodsCombined irradiation and imaging experiments were performed using static proton pencil beam irradiation, background-nulled inversion recovery (IR) MRI and a range of flow-restricted phantoms differing in initial oxygen concentration and homogeneity. The similarity of the irradiation-induced MRI contrast to the proton pencil beam dose distribution acquired on radiochromic film, the expected dose dependence and temporal stability, the TR dependence as well as the dependence on the initial oxygen concentration and the oxygen consumption rate were tested. Moreover, the feasibility of oxygen depletion-based beam visualization in tissue-mimicking phantoms was assessed. The levels of irradiation-induced oxygen depletion and
resultsThe proton irradiation-induced contrast in background-nulled IR images of well oxygenated phantoms was found similar to the proton pencil beam dose distribution and showed the characteristics expected for oxygen depletion-induced MRI contrast. No beam-induced contrast was observed in the poorly oxygenated, inhomogeneous tissue-mimicking phantoms.
conclusionsProton beam-induced radiochemical oxygen depletion can be visualized using
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