ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025
Impact of signs and symptoms of dry eye disease on health-related quality of life: a cross-sectional population study among older adults.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Yoga as a cost-effective adjunct therapy for dry eye: clinical outcomes from a 12-week randomized controlled trial.Frontiers in medicine · 2026Trial
- Apparent protective associations between smoking, alcohol consumption, and dry eye disease: evidence from a community-based Adult Dry Eye Cohort (ADEC) in Beijing.BMC public health · 2026Article
- The Dry Eye dAily Life (DEAL) Questionnaire: Psychometric Validation of a New Instrument for Measuring the Impact of Dry Eye on Daily Life and Patient Satisfaction While Using Eye Drops.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
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8 authors.
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Abstract
purposeTo assess the relationship between quality of life (QoL) and ocular surface health within a Finnish population-based cohort.
methodsA cross-sectional study involved 601 individuals born between the years 1933-1956. Ocular surface health and dry eye disease (DED) were clinically evaluated using several diagnostic tests. Participants completed the Ocular Surface Disease Index (OSDI), QoL assessment with the 15D and Medical Outcomes Study 36-Item Short Form Health Survey (SF-36), and the Beck's Depression Inventory (BDI-II) questionnaires. Various statistical methods were employed to explore the associations between QoL, ocular surface health, and sex disparities.
resultsDED had negative impact on QoL in all participants, and especially in women. Adjusted for comorbidities, DED doubled the odds of worse health-related QoL (15D: OR = 2.31 [95% CI: 1.24-4.31, p < 0.01]) and mental health (SF-36 MCS and BDI-II: OR = 2.08 [95% CI: 1.04-4.16, p < 0.05]). Noninvasive tear break-up time (NIBUT) correlated with all QoL scores. In women, the most significant clinical signs correlating with low QoL were NIBUT (15D: r = 0.20, p = 0.002; SF-36 MCS: r = 0.18, p = 0.026), and conjunctival staining (15D: r=-0.19, p = 0.004; BDI-II: r = 0.27, p < 0.001), whereas in men, blepharitis correlated with depression score (BDI-II: r = 0.20, p = 0.036). High OSDI was associated with worse QoL in women, but not in men.
conclusionThis first population-based study assessing general QoL data with objective clinical measures of DED indicated that among elderly population, both symptoms and signs of DED independently impacted different aspects of QoL. In addition, significant sex-differences in these associations were observed and should be considered both in research settings and when assessing and treating people with DED.
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