Observational studyEuropean heart journal2025
Tricuspid regurgitation and outcomes in mitral valve transcatheter edge-to-edge repair.
Observational study in European heart journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
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Who cites it
6 citing papers in PubMed.
- Prediction of long-term survival in patients with concomitant pulmonary hypertension and its subtypes after successful transcatheter edge-to-edge mitral valve repair.Cardiovascular diagnosis and therapy · 2026Article
- Prognosis of tricuspid regurgitation after mitral transcatheter edge-to-edge repair: the EXPANDed studies.ESC heart failure · 2026Observational
- Worsening tricuspid regurgitation following a successful mitral valve procedure: how to manage.European heart journal supplements : journal of the European Society of Cardiology · 2026Article
- Transthoracic and Transesophageal Echocardiography in the Diagnosis and Management of Mitral Regurgitation.Current cardiology reports · 2025Review
- Prognostic Impact of Modified J-MACS Score in Patients With Systolic Heart Failure Receiving Transcatheter Edge-to-Edge Mitral Valve Repair.Journal of the American Heart Association · 2025Observational
- Beyond multivalvular disease: imaging-guided diagnosis and management of combined functional mitral and tricuspid regurgitation.European heart journal. Imaging methods and practice · 2025Article
Corrections and comments
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Authors and funding
28 authors.
Funding
Abstract
BACKGROUND AND
aimsThe association between periprocedural change in tricuspid regurgitation (TR) and outcomes in patients undergoing mitral transcatheter edge-to-edge repair (M-TEER) is unclear. This study aimed to examine the prognostic value of TR before and after M-TEER.
methodsPatients in the OCEAN-Mitral registry were divided into four groups according to baseline and post-procedure echocardiographic assessments: no TR/no TR (no TR), no TR/significant TR (new-onset TR), significant TR/no TR (normalized TR), and significant TR/significant TR (residual TR) (all represents before/after M-TEER). Tricuspid regurgitation ≥ moderate was defined as significant. The primary outcome was cardiovascular death or heart failure hospitalization. Tricuspid regurgitation pressure gradient was also evaluated.
resultsThe numbers of patients in each group were 2103 (no TR), 201 (new-onset TR), 504 (normalized TR), and 858 (residual TR). Baseline assessment for TR and TR pressure gradient was not associated with outcomes after M-TEER. In contrast, patients with new-onset TR had the highest adjusted risk for the primary outcome, followed by those with residual TR [compared with no TR as a reference, hazard ratio 1.83 (95% confidence interval: 1.39-2.40) for new-onset TR, 1.45 (1.23-1.72) for residual TR, and 0.82 (0.65-1.04) for normalized TR]. Similarly, from baseline to post-procedure, TR pressure gradient changes were associated with subsequent outcomes after M-TEER. New-onset and residual TR incidence was commonly associated with dilated tricuspid annulus diameter and atrial fibrillation.
conclusionsPost-procedural TR, but not baseline TR, was associated with outcomes after M-TEER. Careful TR assessment after the procedure would provide an optimal management for concomitant significant TR in patients undergoing M-TEER.
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