Evidence map›Paper›PMID 39873665›Full record

ArticleeLife2025

Progesterone induces meiosis through two obligate co-receptors with PLA2 activity.

Nancy Nader, Lama Assaf, Lubna Zarif, Anna Halama, Sharan Yadav, Maya Dib, Nabeel Attarwala, Qiuying Chen, Karsten Suhre, Steven Gross and 1 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nancy NaderCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.ORCID https://orcid.org/0000-0003-1688-8174
Lama AssafCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.
Lubna ZarifCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.
Anna HalamaDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, United States.
Sharan YadavCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.
Maya DibCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.
Nabeel AttarwalaDepartment of Pharmacology, Weill Cornell Medicine, New York, United States.
Qiuying ChenDepartment of Pharmacology, Weill Cornell Medicine, New York, United States.ORCID https://orcid.org/0000-0001-5909-3959
Karsten SuhreDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, United States.
Steven GrossDepartment of Pharmacology, Weill Cornell Medicine, New York, United States.
Khaled MachacaCalcium Signaling Group, Research Department, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.ORCID https://orcid.org/0000-0001-6215-2411

Funding

Metabolic remodeling of skeletal muscle in mitochondrial myopathiesR01AR076029 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, QIUYING, D'AURELIO, MARILENA · 2020 to 2024
$2.7M
Pho-m6A assay: A phosphoselective method to quantify dynamics of m6A in mRNAR21ES032347 · NIEHS · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHEN, QIUYING, JAFFREY, SAMIE R · 2020 to 2021
$466k
NIAMS NIH HHS R01 AR076029NIEHS NIH HHS R21 ES032347NIH Blueprint for Neuroscience Research R21ES032347NIH Office of the Director R01AR076029Qatar Foundation BMRPQatar National Research Fund NPRP13S-0206-200274
6 · The paper itself

Abstract

The steroid hormone progesterone (P4) regulates multiple aspects of reproductive and metabolic physiology. Classical P4 signaling operates through nuclear receptors that regulate transcription. In addition, P4 signals through membrane P4 receptors (mPRs) in a rapid nongenomic modality. Despite the established physiological importance of P4 nongenomic signaling, the details of its signal transduction cascade remain elusive. Here, using

Indexed as

MeiosisPhospholipases A2ProgesteroneReceptors, ProgesteroneAnimalsFemaleOocytesSignal TransductionXenopus laevisPhospholipases A2ProgesteroneReceptors, ProgesteroneABHD2cell biologylipid messengersmembrane progesterone receptor betanongenomic signalingPLA2progesteronexenopus

Identifiers

PMID39873665
PMCPMC11774516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.