ArticleAnnals of medicine2025
Demographics and outcomes of acute type A aortic dissection in young adults in southeastern China: impact of syndromic heritable thoracic aortic disease.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Concomitant Aortic Root Replacement in Total Arch Replacement With Frozen Elephant Trunk for Type A Aortic Dissection: A Propensity-Weighted Analysis.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026Article
- Admission creatinine level predicts postoperative acute hepatic dysfunction in patients aged ≤30 years with acute type A aortic dissection: a multi-center retrospective study.Frontiers in cardiovascular medicine · 2026Article
- Catastrophic Acute Aortic Dissection in a Young Healthy Patient.JACC. Case reports · 2025Article
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6 authors.
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Abstract
backgroundThis study aimed to investigate the demographics and to evaluate long-term outcomes of acute type A aortic dissection (ATAAD) in surgically treated patients ≤40 years in China.
methodsThis study included patients aged ≤40 with ATAAD who underwent surgical treatment at our institution between 2015 and 2019. The patients were categorized into groups according to heritable thoracic aortic disease (HTAD) presence or absence. The primary outcomes were in-hospital and late mortality, and aortic-related re-intervention.
resultsOur cohort included 141 patients aged ≤ 40, representing 14.6% of all patients with ATAAD treated during the same period. 35.5% (50 of 141) of these cases were associated with HTAD. Among them, only 16.0% were aware of their condition prior to the occurrence of ATAAD. Most patients underwent extensive arch procedures and in-hospital mortality rate of patients was 14.2%, which was higher in the HTAD group than in the non-HTAD group (20.0% vs. 11.0%,
conclusionsThe prevalence of HTAD is high in the cohort of younger patients with ATAAD. HTAD is associated with high rates of in-hospital mortality and late reoperation. Extensive primary aortic repair is safe and has long-term benefits in young patients with ATAAD. Regular imaging assessment of the thoracoabdominal aorta after surgery is imperative for improving the long-term prognosis.
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