Evidence map›Paper›PMID 39873623›Full record

ArticleScience immunology2025

The meninges host a distinct compartment of regulatory T cells that preserves brain homeostasis.

Miguel Marin-Rodero, Elisa Cintado, Alec J Walker, Teshika Jayewickreme, Felipe A Pinho-Ribeiro, Quentin Richardson, Ruaidhrí Jackson, Isaac M Chiu, Christophe Benoist, Beth Stevens and 2 more

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Article
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  6. Mechanisms, Microenvironments, and Models: Understanding Therapeutic Resistance in Glioblastoma.International journal of radiation oncology, biology, physics · 2026
    Review
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  11. CD38 endows local antigen-specific TNature immunology · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Miguel Marin-RoderoDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-8659-7706
Elisa CintadoCajal Institute, Translational Neuroscience Department, Consejo Superior de Investigaciones Científicas, Madrid, Spain.ORCID 0000-0002-1943-4664
Alec J WalkerF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-7619-0662
Teshika JayewickremeDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-8075-7251
Felipe A Pinho-RibeiroDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-4264-9839
Quentin RichardsonDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Ruaidhrí JacksonDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Isaac M ChiuDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0723-4841
Christophe BenoistDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1172-6555
Beth StevensF. M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0003-4226-1201
José Luís TrejoCajal Institute, Translational Neuroscience Department, Consejo Superior de Investigaciones Científicas, Madrid, Spain.ORCID 0000-0003-0618-5547
Diane MathisDepartment of Immunology, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6110-4626

Funding

Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 2020 to 2026
$28.7M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Staphylococcus aureus induced itch and neuro-immune signaling in skin infectionsR01AI168005 · NIAID · HARVARD MEDICAL SCHOOL · PI Isaac Ming-Cheng Chiu, ALEXANDER R HORSWILL · 2022 to 2026
$3.7M
Illuminating the immune system's genomic dark matter: functionally annotating the hidden translatomeDP2AI169979 · NIAID · HARVARD MEDICAL SCHOOL · PI JACKSON, RUAIDHRI · 2021 to 2024
$2.5M
Nociceptor neuron regulation of gastrointestinal barrier protection and host defenseR01DK127257 · NIDDK · HARVARD MEDICAL SCHOOL · PI CHIU, ISAAC MING-CHENG · 2021 to 2024
$2.2M
NIAID NIH HHS DP2 AI169979NIAID NIH HHS R01 AI168005NIA NIH HHS P30 AG066444NIDDK NIH HHS R01 DK127257NIGMS NIH HHS T32 GM144273
6 · The paper itself

Abstract

Our understanding of the meningeal immune system has recently burgeoned, particularly regarding how innate and adaptive effector cells are mobilized to meet brain challenges. However, information on how meningeal immunocytes guard brain homeostasis in healthy individuals remains limited. This study highlights the heterogeneous, polyfunctional regulatory T cell (T

Indexed as

BrainHomeostasisMeningesT-Lymphocytes, RegulatoryAnimalsB-LymphocytesFemaleInterferon-gammaMaleMiceMice, Inbred C57BLInterferon-gamma

Identifiers

PMID39873623
PMCPMC11924117

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.