Evidence map›Paper›PMID 39873598›Full record

ReviewRadiology2025

Open-Source Large Language Models in Radiology: A Review and Tutorial for Practical Research and Clinical Deployment.

Cody H Savage, Adway Kanhere, Vishwa Parekh, Curtis P Langlotz, Anupam Joshi, Heng Huang, Florence X Doo

Abstract readReview
In one paragraph

Review in Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cody H SavageFrom the University of Maryland Medical Intelligent Imaging (UM2ii) Center, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (C.H.S., A.K., V.P., F.X.D.); Departments of Radiology, Medicine, and Biomedical Data Science, Stanford University, Palo Alto, Calif (C.P.L.); Department of Computer Science and Electrical Engineering, College of Engineering and Information Technology, University of Maryland, Baltimore County, Baltimore, Md (A.J.); Department of Computer Science, University of Maryland, College Park, College Park, Md (H.H.); and University of Maryland Institute for Health Computing, University of Maryland, North Bethesda, Md (H.H., F.X.D.).ORCID 0000-0001-6854-1397
Adway KanhereFrom the University of Maryland Medical Intelligent Imaging (UM2ii) Center, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (C.H.S., A.K., V.P., F.X.D.); Departments of Radiology, Medicine, and Biomedical Data Science, Stanford University, Palo Alto, Calif (C.P.L.); Department of Computer Science and Electrical Engineering, College of Engineering and Information Technology, University of Maryland, Baltimore County, Baltimore, Md (A.J.); Department of Computer Science, University of Maryland, College Park, College Park, Md (H.H.); and University of Maryland Institute for Health Computing, University of Maryland, North Bethesda, Md (H.H., F.X.D.).ORCID 0000-0001-5295-2634
Vishwa ParekhFrom the University of Maryland Medical Intelligent Imaging (UM2ii) Center, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (C.H.S., A.K., V.P., F.X.D.); Departments of Radiology, Medicine, and Biomedical Data Science, Stanford University, Palo Alto, Calif (C.P.L.); Department of Computer Science and Electrical Engineering, College of Engineering and Information Technology, University of Maryland, Baltimore County, Baltimore, Md (A.J.); Department of Computer Science, University of Maryland, College Park, College Park, Md (H.H.); and University of Maryland Institute for Health Computing, University of Maryland, North Bethesda, Md (H.H., F.X.D.).ORCID 0000-0002-6306-0305
Curtis P LanglotzFrom the University of Maryland Medical Intelligent Imaging (UM2ii) Center, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (C.H.S., A.K., V.P., F.X.D.); Departments of Radiology, Medicine, and Biomedical Data Science, Stanford University, Palo Alto, Calif (C.P.L.); Department of Computer Science and Electrical Engineering, College of Engineering and Information Technology, University of Maryland, Baltimore County, Baltimore, Md (A.J.); Department of Computer Science, University of Maryland, College Park, College Park, Md (H.H.); and University of Maryland Institute for Health Computing, University of Maryland, North Bethesda, Md (H.H., F.X.D.).ORCID 0000-0002-8972-8051
Anupam JoshiFrom the University of Maryland Medical Intelligent Imaging (UM2ii) Center, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (C.H.S., A.K., V.P., F.X.D.); Departments of Radiology, Medicine, and Biomedical Data Science, Stanford University, Palo Alto, Calif (C.P.L.); Department of Computer Science and Electrical Engineering, College of Engineering and Information Technology, University of Maryland, Baltimore County, Baltimore, Md (A.J.); Department of Computer Science, University of Maryland, College Park, College Park, Md (H.H.); and University of Maryland Institute for Health Computing, University of Maryland, North Bethesda, Md (H.H., F.X.D.).ORCID 0000-0002-8641-3193
Heng HuangFrom the University of Maryland Medical Intelligent Imaging (UM2ii) Center, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (C.H.S., A.K., V.P., F.X.D.); Departments of Radiology, Medicine, and Biomedical Data Science, Stanford University, Palo Alto, Calif (C.P.L.); Department of Computer Science and Electrical Engineering, College of Engineering and Information Technology, University of Maryland, Baltimore County, Baltimore, Md (A.J.); Department of Computer Science, University of Maryland, College Park, College Park, Md (H.H.); and University of Maryland Institute for Health Computing, University of Maryland, North Bethesda, Md (H.H., F.X.D.).ORCID 0000-0002-3483-8333
Florence X DooFrom the University of Maryland Medical Intelligent Imaging (UM2ii) Center, Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (C.H.S., A.K., V.P., F.X.D.); Departments of Radiology, Medicine, and Biomedical Data Science, Stanford University, Palo Alto, Calif (C.P.L.); Department of Computer Science and Electrical Engineering, College of Engineering and Information Technology, University of Maryland, Baltimore County, Baltimore, Md (A.J.); Department of Computer Science, University of Maryland, College Park, College Park, Md (H.H.); and University of Maryland Institute for Health Computing, University of Maryland, North Bethesda, Md (H.H., F.X.D.).ORCID 0000-0001-6519-5222

Funding

Understanding and addressing risks of low socioeconomic status and diabetes for heart failureP50MD017348 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI COMMODORE-MENSAH, YVONNE · 2021 to 2025
$24.2M
Ultrascale Machine Learning to Empower Discovery in Alzheimers Disease BiobanksU01AG068057 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Christos Davatzikos, Heng Huang · 2020 to 2026
$20.7M
MEDICAL IMAGING AND DATA RESOURCE CENTER (MIDRC) YEAR 375N92020D00021 · NIBIB · UNIVERSITY OF CHICAGO · PI GIGER, MARYELLEN · 2021 to 2025
$16.6M
New statistical methods and software for modeling complex multivariate survival data with large-scale covariatesR01GM141076 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DING, YING · 2022 to 2025
$1.2M
SCH: New Advanced Machine Learning Framework for Mining Heterogeneous Ocular Data to AccelerateR01EB034116 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI Wei Chen, Heng Huang · 2022 to 2026
$1.2M
Virtual nanostructure simulation (VINAS) portalR01GM148743 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Hao Zhu · 2023 to 2026
$1.1M
NHLBI NIH HHS 75N92020D00021NIA NIH HHS U01 AG068057NIBIB NIH HHS R01 EB034116NIGMS NIH HHS R01 GM141076NIGMS NIH HHS R01 GM148743NIMHD NIH HHS P50 MD017348
6 · The paper itself

Abstract

Integrating large language models (LLMs) into health care holds substantial potential to enhance clinical workflows and care delivery. However, LLMs also pose serious risks if integration is not thoughtfully executed, with complex challenges spanning accuracy, accessibility, privacy, and regulation. Proprietary commercial LLMs (eg, GPT-4 [OpenAI], Claude 3 Sonnet and Claude 3 Opus [Anthropic], Gemini [Google]) have received much attention from researchers in the medical domain, including radiology. Interestingly, open-source LLMs (eg, Llama 3 and LLaVA-Med) have received comparatively little attention. Yet, open-source LLMs hold several key advantages over proprietary LLMs for medical institutions, hospitals, and individual researchers. The wider adoption of open-source LLMs has been slower, perhaps in part due to the lack of familiarity, accessible computational infrastructure, and community-built tools to streamline their local implementation and customize them for specific use cases. Thus, this article provides a tutorial for the implementation of open-source LLMs in radiology, including examples of commonly used tools for text generation and techniques for troubleshooting issues with prompt engineering, retrieval-augmented generation, and fine-tuning. Implementation-ready code for each tool is provided at

Indexed as

Programming LanguagesRadiologyRadiology Information SystemsHumansLarge Language Models

Identifiers

PMID39873598
PMCPMC11783163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.