Evidence map›Paper›PMID 39873486›Full record

ArticlemBio2025

Frequently arising ESX-1-associated phase variants influence

Michael J Luna, Peter O Oluoch, Jiazheng Miao, Peter Culviner, Kadamba Papavinasasundaram, Eleni Jaecklein, Scarlet S Shell, Thomas R Ioerger, Sarah M Fortune, Maha R Farhat and 1 more

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Journal of bacteriology · 2026
    Review
  5. Article
  6. Review
  7. Control of antigen presentation on MHC-I by a bacterial secretion system.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. UShER-TB: Scalable, Comprehensive, Accessible Phylogenomic Analysis ofmedRxiv : the preprint server for health sciences · 2025
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michael J LunaDepartment of Microbiology, UMass Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-9751-0829
Peter O OluochDepartment of Microbiology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Jiazheng MiaoDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
Peter CulvinerDepartment of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
Kadamba PapavinasasundaramDepartment of Microbiology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Eleni JaeckleinDepartment of Microbiology, UMass Chan Medical School, Worcester, Massachusetts, USA.
Scarlet S ShellDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.ORCID 0000-0003-1136-1728
Thomas R IoergerDepartment of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA.
Sarah M FortuneDepartment of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0001-7565-9975
Maha R FarhatDepartment of Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA.
Christopher M SassettiDepartment of Microbiology, UMass Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0001-6178-4329

Funding

Surviving evolution: Short-term adaptations for fitnessP01AI143575 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JAMES C SACCHETTINI · 2020 to 2026
$18.2M
Gerome Wide Association Study of Bacterial Determinants of Clinical Response in TuberculosisU19AI142793 · NIAID · HARVARD MEDICAL SCHOOL · PI FORTUNE, SARAH · 2019 to 2023
$14.6M
Systems Biology CoreU19AI162598 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ALLAND, DAVID, ELLNER, JERROLD J. · 2021 to 2025
$13.9M
Systems Genetics of TuberculosisP01AI181898 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CHRISTOPHER M SASSETTI · 2024 to 2026
$10.5M
The roles of sRNA in the physiology and pathogenesis of Mycobacterium abscessus and other mycobacteriaR21AI156415 · NIAID · WORCESTER POLYTECHNIC INSTITUTE · PI SHELL, SCARLET SARA · 2021 to 2022
$395k
Dissecting virulence gene regulatory pathways in M. tuberculosis clinical isolatesF32AI174653 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Peter H Culviner · 2024 to 2026
$248k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI143575HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI156415HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI162598HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI181898HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) F32AI174653HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32A100734NIAID NIH HHS F32 AI174653NIAID NIH HHS P01 AI143575NIAID NIH HHS P01 AI181898NIAID NIH HHS R21 AI156415NIAID NIH HHS U19 AI142793NIAID NIH HHS U19 AI162598
6 · The paper itself

Abstract

IMPORTANCE:

Indexed as

Antitubercular AgentsBacterial ProteinsGenetic FitnessMycobacterium tuberculosisType VII Secretion SystemsAnimalsDrug Resistance, BacterialGene Expression Regulation, BacterialINDEL MutationMiceTuberculosisAntitubercular AgentsBacterial ProteinsType VII Secretion Systemsbacterial geneticsphase variationtuberculosis

Identifiers

PMID39873486
PMCPMC11898584

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.