Evidence map›Paper›PMID 39873425›Full record

ArticleJournal of cellular and molecular medicine2025

Temozolomide-Promoted MGMT Transcription Contributes to Chemoresistance by Activating the ERK Signalling Pathway in Malignant Melanoma.

Meiyi Deng, Bingjie Ren, Jing Zhao, Xia Guo, Yuanyuan Yang, Huiling Shi, Xuyu Bian, Mengyao Wu, Caihua Xu, Min Tao and 2 more

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Role of non-coding RNAs in OOncology letters · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Meiyi DengDepartment of Oncology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Bingjie RenDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Jing ZhaoDepartment of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xia GuoDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yuanyuan YangDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Huiling ShiDepartment of Oncology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Xuyu BianDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Mengyao WuDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Caihua XuDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Min TaoDepartment of Oncology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Rongrui LiangDepartment of Oncology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.ORCID 0000-0001-9879-2808
Qiang LiDepartment of Chemotherapy, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China.ORCID 0009-0009-8914-4521

Funding

Beijing Xisike Clinical Oncology Research Foundation Y-HH202101-0059Clinical Medicine peak project of Soochow Medical College, Soochow University ML42900423Clinical Research Project of Wu Jieping Medical Foundation 320.6750.2021-16-62Gusu Health Talent Program GSWS2023072Jiangsu Government Scholarship for Oversea StudiesSuzhou Science and Technology Plan SKY2022092Suzhou Science and Technology Plan SZM2021012Suzhou Science and Technology Plan SZM2022009the National Natural Science Foundation of China 82373204The Open Fund for Scientific Research of Jiangxi Cancer Hospital 2021J08
6 · The paper itself

Abstract

Tumour cells possess a multitude of chemoresistance mechanisms, which could plausibly contribute to the ineffectiveness of chemotherapy. O

Indexed as

DNA Modification MethylasesDNA Repair EnzymesDrug Resistance, NeoplasmMAP Kinase Signaling SystemMelanomaTemozolomideTranscription, GeneticTumor Suppressor ProteinsAnimalsAntineoplastic Agents, AlkylatingApoptosisCell Line, TumorDNA DamageGene Expression Regulation, NeoplasticHumansMiceAntineoplastic Agents, AlkylatingDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTemozolomideTumor Suppressor ProteinsVemurafenibchemoresistanceMAPK/ERK pathwaymelanomaMGMTtemozolomide

Identifiers

PMID39873425
PMCPMC11773391

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.