Evidence map›Paper›PMID 39873146›Full record

ArticleAmerican journal of hematology2025

TP53 Mutations in Myeloproliferative Neoplasms: Context-Dependent Evaluation of Prognostic Relevance.

Ayalew Tefferi, Maymona Abdelmagid, Giuseppe G Loscocco, Saubia Fathima, Kebede H Begna, Aref Al-Kali, James Foran, Jeanne Palmer, Talha Badar, Mrinal M Patnaik and 11 more

Abstract read
In one paragraph

Article in American journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Unraveling the role ofHemaSphere · 2026
    Review
  9. The Role and Impact of Non-driver Gene Mutations in Myelofibrosis.Current hematologic malignancy reports · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Ayalew TefferiDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-4605-3821
Maymona AbdelmagidDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Giuseppe G LoscoccoDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-6241-1206
Saubia FathimaDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Kebede H BegnaDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0003-2730-8593
Aref Al-KaliDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-0824-3715
James ForanDivision of Hematology, Mayo Clinic, Jacksonville, Florida, USA.
Jeanne PalmerDivision of Hematology, Mayo Clinic, Scottsdale, ARZ, USA.
Talha BadarDivision of Hematology, Mayo Clinic, Jacksonville, Florida, USA.ORCID 0000-0003-1548-918X
Mrinal M PatnaikDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6998-662X
Kaaren K ReichardDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Rong HeDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6116-8163
Cinthya J Zepeda MendozaDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-0434-4965
Mithun ShahDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-5359-336X
Attilio OraziDepartment of Pathology, Texas Tech University Health Sciences Center, El Paso, Texas, USA.ORCID 0000-0002-1660-7013
Daniel A ArberDepartment of Pathology, University of Chicago, Chicago, Illinois, USA.ORCID 0000-0002-2160-9689
Animesh PardananiDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-9084-4148
Alessandro M VannucchiCRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy.ORCID 0000-0001-5755-0730
Devendra HiwaseDepartment of Haematology, Royal Adelaide Hospital and South Australian Health and Medical Research Institute, Adelaide, Australia.ORCID 0000-0002-6666-3056
Naseema GangatDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-9104-6172
Paola GuglielmelliCRIMM, Center Research and Innovation of Myeloproliferative Neoplasms, University of Florence, AOU Careggi, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical relevance of TP53 mutations (TP53

Indexed as

MutationMyeloproliferative DisordersTumor Suppressor Protein p53AdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisTP53 protein, humanTumor Suppressor Protein p53ICCkaryotypeprognosissurvivalWHO

Identifiers

PMID39873146
PMCPMC11886478

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.