ArticleLife medicine2023
A comparative study of metformin and nicotinamide riboside in alleviating tissue aging in rats.
Article in Life medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Restoring the FOXO1 geroprotective pathway via seno-resistant mesenchymal progenitor cells alleviates primate epididymal aging.Protein & cell · 2026Article
- Sex-specific aging clocks from a large-scale human phenome reveal distinct aging transitions and circulating signatures.Nature aging · 2026Article
- Integrative Approaches to Treating Cellular Senescence in Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Succinate dehydrogenase-deficient cancer cells have increased susceptibility to Ym155-induced DNA damage.Endocrine-related cancer · 2026Article
- Interconnected Pathways and Therapeutic Implications for Cardiovascular Aging and Diseases.JACC. Asia · 2026Review
- Causal relationships between cerebrospinal fluid metabolites, immune cell traits, and head and neck cancers.Discover oncology · 2025Article
- Single-cell profiling identifies hair cell SLC35F1 deficiency as a signature of primate cochlear aging.Nature aging · 2025Article
- Gene therapy strategies for aging intervention.Cell insight · 2025Review
- SIRT5 safeguards against primate skeletal muscle ageing via desuccinylation of TBK1.Nature metabolism · 2025Article
- CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver.Nucleic acids research · 2024Article
- Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling.Protein & cell · 2024Article
- Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner.Protein & cell · 2024Article
- SGF29 nuclear condensates reinforce cellular aging.Cell discovery · 2023Article
- SenoIndex: S100A8/S100A9 as a novel aging biomarker.Life medicine · 2023Article
- Biomarkers of aging.Science China. Life sciences · 2023Review
- MAVS Antagonizes Human Stem Cell Senescence as a Mitochondrial Stabilizer.Research (Washington, D.C.) · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metformin (MET) and nicotinamide riboside (NR) have both been reported to exert geroprotective effects in multiple species. However, the mechanism by which MET and NR regulate the aging program and delay aging in multiple tissues remains unclear. Here, we demonstrated that MET and NR attenuate aging features in human mesenchymal stem cells. Moreover, by systematically investigating the pathophysiological changes in different tissues from aged rats after oral administration of MET and NR, we showed that both MET and NR treatment alleviated various aging-related characteristics in multiple tissues, including inflammation, fibrosis, and protein aggregates. Consistently, MET or NR treatment partially rescued aging-related gene expression changes in aged rats. Collectively, we report that both MET and NR attenuate senescence phenotypes in human stem cells
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