Development and application of an efficient, accurate, and environmentally friendly liquid chromatography-tandem mass spectrometry method for the determination of five Alternaria toxins in wheat.

Huiyuan Lang, Zengwang Guo, Yu Wu, Li Li, Hongmei Liu, Lianzhou Jiang, Songxue Wang, Jin Ye

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Article in Food chemistry: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Huiyuan LangCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China.

Zengwang GuoCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China.

Yu WuAcademy of National Food and Strategic Reserves Administration, NFSRA Key Laboratory of Grain and oil quality and safety, Beijing 100037, China.

Li LiAcademy of National Food and Strategic Reserves Administration, NFSRA Key Laboratory of Grain and oil quality and safety, Beijing 100037, China.

Hongmei LiuAcademy of National Food and Strategic Reserves Administration, NFSRA Key Laboratory of Grain and oil quality and safety, Beijing 100037, China.

Lianzhou JiangCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, China.

Songxue WangAcademy of National Food and Strategic Reserves Administration, NFSRA Key Laboratory of Grain and oil quality and safety, Beijing 100037, China.

Jin YeAcademy of National Food and Strategic Reserves Administration, NFSRA Key Laboratory of Grain and oil quality and safety, Beijing 100037, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contamination of Alternaria toxins poses a potential risk to human health. This study developed a rapid, efficient, and environmentally friendly method for the simultaneous determination of five types of Alternaria toxins in wheat using high-precision and stable isotope liquid chromatography tandem mass spectrometry. The comparison between dilution method and solid-phase extraction method shows that the former achieves satisfactory results with a simple and convenient sample purification method. The quantitative limit range is 0.88 to 1.68 μg/kg. The recoveries are between 81.40% and 102.68%, with RSD less than 11.95%. The method was used to analyze 60 samples from the main wheat producing areas in China. The results showed that Tenuzonic acid had the highest detection rate (100%), followed by Tentoxin (95%), Alternariol (66.67%), and Alternariol monomethyl ether (53.33%). There is a certain pollution risk that needs to be taken seriously and monitoring should be strengthened.

Indexed as

Alternaria toxinsContamination assessmentDilution methodLC-MS/MSWheat

Identifiers

PMID39872824

DOI10.1016/j.fochx.2025.102167

PMCPMC11770498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.