ArticleIn vitro models2022
Characterization of non-solvent- and thermal-induced phase separation applied polycaprolactone/demineralized bone matrix scaffold for bone tissue engineering.
Article in In vitro models, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Bone-Mimetic Osteon Microtopographies on Poly-ε-Caprolactone Enhance the Osteogenic Potential of Human Mesenchymal Stem Cells.Macromolecular bioscience · 2025Article
- A Review of 3D Polymeric Scaffolds for Bone Tissue Engineering: Principles, Fabrication Techniques, Immunomodulatory Roles, and Challenges.Bioengineering (Basel, Switzerland) · 2023Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Polycaprolactone (PCL) is a widely applied biomaterial in bone tissue engineering (BTE) due to its superior mechanical properties and biodegradability. However, the high hydrophobicity and low cell adhesion properties of PCL show limited cell interactions. Herein, we prepared the porous PCL/DBP composites with improved cell adhesion through the addition of demineralized bone powder (DBP). Three-dimensional scaffolds were fabricated by mixing various concentrations of DBP with PCL and applying non-solvent-induced phase separation (NIPS) and thermal-induced phase separation (TIPS) (N-TIPS) and solvent casting and particulate leaching (SCPL) to impart porosity. Methods: A characteristic evaluation was performed through X-ray diffraction (XRD), morphological analysis, physicochemical analysis, bioactivity test, and mechanical test. Upon culture with mouse bone marrow stem cells (mBMSCs), proliferation and osteogenic differentiation of mBMSC were evaluated using quantitative dsDNA analysis and alkaline phosphatase (ALP) activity, respectively. Results: The addition of DBP improved the physicochemical and mechanical properties of the scaffold and formed a large amount of hydroxyapatite (HAp). Also, cell proliferation and differentiation were increased by enhancing cell adhesion. Conclusion: The porous PCL/DBP scaffolds could provide a favorable microenvironment for cell adhesion and be a promising biomaterial model for bone tissue engineering. Graphical abstract:
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