Evidence map›Paper›PMID 39872708›Full record

ArticleCase reports in gastrointestinal medicine2025

Disseminated Chickenpox Following Live Varicella Vaccination in a Crohn's Disease Patient on Combination Immunosuppression.

Quintin Solano, Sarah Uttal, Peter D R Higgins, Jeffrey A Berinstein

Abstract readCase Reports
In one paragraph

Article in Case reports in gastrointestinal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Quintin SolanoDepartment of Internal Medicine, Michigan Medicine, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-5195-8601
Sarah UttalDepartment of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-5173-5873
Peter D R HigginsDepartment of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-1602-4341
Jeffrey A BerinsteinDepartment of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0001-7631-9665

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel therapeutics used in the treatment of inflammatory bowel disease pose an increased risk of viral reactivation in patients. We present a case of a patient with refractory Crohn's disease (CD) who developed primary varicella (chickenpox) of a vaccine-viral strain after receiving combination immunosuppression with high-dose corticosteroids, tumor necrosis factor inhibitor (TNFi), and a Janus kinase inhibitor (JAKi) in the hospital. While this patient recovered and did not experience long term adverse effects, her case provides an opportunity for improvement. To improve safety, healthcare facilities should develop protocols that use electronic medical records enhanced with clinical decision support systems to identify and protect immunocompromised patients from inappropriate live vaccinations.

Identifiers

PMID39872708
PMCPMC11772060

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.