Evidence map›Paper›PMID 39872681›Full record

ArticleJAC-antimicrobial resistance2025

Defining and responding to the contextual drivers for implementation of antimicrobial stewardship in 14 neonatal units in South Africa.

Dena Van Den Bergh, Esmita Charani, Angela Dramowski, Ama Sakoa Annor, Michelle Gijzelaar, Angeliki Messina, Andriette Van Jaarsveld, Debra A Goff, Pavel Prusakov, Liezl Balfour and 30 more

Abstract read
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In one paragraph

Article in JAC-antimicrobial resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Dena Van Den BerghDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0003-4057-4925
Esmita CharaniDivision of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Angela DramowskiDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Ama Sakoa AnnorDepartment of Pharmacy, Dr George Mukhari Academic Hospital, Pretoria, South Africa.ORCID https://orcid.org/0009-0001-7249-0980
Michelle GijzelaarDepartment of Pharmacy, Life Healthcare Group, Illovo, South Africa.
Angeliki MessinaAntimicrobial Stewardship Unit, Netcare Hospitals Ltd, Johannesburg, South Africa.
Andriette Van JaarsveldDepartment of Pharmacy Mediclinic Southern Africa, Stellenbosch, South Africa.ORCID https://orcid.org/0000-0003-4325-5567
Debra A GoffThe Ohio State University College of Pharmacy, The Ohio State University Wexner Medical Center, Columbus, OH, USA.ORCID https://orcid.org/0000-0001-7686-0670
Pavel PrusakovMerck & Co, Inc, Rahway, NJ, USA.
Liezl BalfourDepartment of Nursing, Lenmed Group, Johannesburg, South Africa.
Adrie BekkerDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Azraa CassimDepartment of Pharmacy, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.
Nelesh P GovenderNational Institute for Communicable Diseases, Division of the National Health Laboratory Service, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-7869-9462
Sandi L HolgateDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Sonya KolmanDepartment of Pharmacy, Nelson Mandela Children's Hospital, Johannesburg, South Africa.
Hafsah TootlaDivision of Medical Microbiology, University of Cape Town, Cape Town, South Africa.
Natalie SchellackDepartment of Pharmacology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.ORCID https://orcid.org/0000-0001-9690-6285
Kessendri ReddyDivision of Medical Microbiology and Immunology, Department of Pathology, Faculty of Medicine and Health Sciences, National Health Laboratory Service Tygerberg and Stellenbosch University, Cape Town, South Africa.
Christine FisherDepartment of Nursing, Department of Paediatrics and Child Health, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Lucinda ConradiePharmacy Department, Mowbray Maternity Hospital, Cape Town, South Africa.
Anika Van NiekerkDivision of Neonatology, Department of Paediatrics and Child Health, Mowbray Maternity Hospital, University of Cape Town, Cape Town, South Africa.
Anje LaubscherPharmacy Department, Netcare Pretoria East Hospital, Pretoria, South Africa.
Pearl AlexanderDepartment of Nursing, Lenmed Royal Hospital & Heart Centre, Kimberley, South Africa.
Thanusha NaidooNeonatal Unit, Lenmed Ethekwini Hospital and Heart Centre, Durban, South Africa.
Magdel DippenaarPharmacy Department, Mediclinic Welkom, Welkom, Free State, South Africa.
Colleen BamfordPathcare, East London, South Africa.
Sharnel BritsPharmacy Department, George Provincial Hospital, George, South Africa.
Pinky ChirwaNeonatal Unit, Nelson Mandela Children's Hospital, Johannesburg, South Africa.
Hannelie ErasmusPharmacy Department, Mediclinic Welkom, Welkom, Free State, South Africa.
Pieter EkermansAmpath Laboratory, National Reference Laboratory, Department of Medical Microbiology, Pretoria, South Africa.
Lerina RungenDepartment of Pharmacy, Lenmed Ethekwini Hospital and Heart Centre, Durban, South Africa.
Teresa KrielPharmacy Department, Life Beacon Bay, East London, South Africa.
Dini MawelaDepartment of Paediatrics and Child Health, School of Medicine, Sefako Makgatho Health Sciences University, Gauteng, South Africa.
Simthembile MjekulaDepartment of Pharmacy, Groote Schuur Hospital, Cape Town, South Africa.
Maphoshane NchabelengDepartment of Medical Microbiology, National Health Laboratory Services, Sefako Makgatho Health Sciences University, Gauteng, South Africa.
Ronald NhariDepartment of Pharmacy, Life Springs Parkland Hospital, Johannesburg, South Africa.
Marli Janse Van RensburgDepartment of Pharmacy, Netcare Unitas Hospital, Pretoria, South Africa.
Pablo J SánchezDepartment of Pediatrics, Divisions of Neonatology and Pediatric Infectious Diseases, Nationwide Children's Hospital, Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.
Adrian BrinkDivision of Medical Microbiology, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-5350-9690
NeoAMS Study Team

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Research on the contextual drivers of antimicrobial stewardship (AMS) programme interventions in neonatal units is limited. Methods: As part of a prospective mixed-methods multidisciplinary neonatal AMS (NeoAMS) interventional study in 14 South African hospitals, we applied a three-phased process to assess implementation barriers and contextual drivers experienced by participating health professionals. The study included: (Phase one; P1) a survey of pre-intervention barriers and enablers; (P2) written feedback during the study intervention phase; and (P3) semi-structured exit interviews. Results: Respondents to the P1 survey ( Conclusions: Understanding the organizational and interprofessional context for NeoAMS implementation enabled an MDT approach to develop and optimize neonatal AMS with potential for adoption in similar resource-constrained settings.

Identifiers

PMID39872681
PMCPMC11770254

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.