ArticleInternational journal of cardiology. Cardiovascular risk and prevention2025
Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris.
Article in International journal of cardiology. Cardiovascular risk and prevention, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Wound-Heart Axis: Can Chronic Wounds Contribute to Cardiac Dysfunction?International journal of molecular sciences · 2026Review
- A Perfect Storm of Pollutants: Environmental Mixtures in the Pathogenesis of Atherosclerosis.International journal of molecular sciences · 2026Review
- Relationship between the miR-146a rs57095329 polymorphism and the risk of peri-implantitis.Journal of periodontal & implant science · 2026Article
- Role of polymorphisms and microRNA levels in predicting cardiovascular events in patients with acute myocardial infarction.World journal of cardiology · 2025Review
- Global Perspectives on Coronary Artery Disease: The Emerging Role of miRNAs.Current atherosclerosis reports · 2025Review
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Authors and funding
8 authors.
Funding
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Abstract
Objective: To investigate the association between plasma miR-146a expression levels, severity of coronary lesions, and clinical prognosis in patients with unstable angina pectoris (UAP). Methods: A total of 100 patients with UAP and 100 controls were selected for assessment of plasma miRNA-146a expression levels. We assessed the severity of coronary lesions in patients with UAP using the Gensini score. Additionally, we analyzed the correlation between miR-146a expression and the degree of coronary artery stenosis in patients with UAP. The incidence of major adverse cardiovascular events (MACEs) was followed-up for 48 months after hospitalization and discharge. The median grouping method was employed to categorize patients into high- and low-expression groups based on their miR-146a levels. Thereafter, the incidence of MACEs in these groups was analyzed using the Kaplan-Meier method. Results: The plasma expression level of miR-146a in the UAP group was 1.8-fold greater than that in the control group (Z = 6.970, P < 0.001) and correlated with the severity of coronary lesions; a high expression level was associated with a higher Gensini score (P < 0.05). Patients with high miR-146a expression levels showed a significantly higher incidence of MACEs than those with low miR-146a expression levels (log-rank test: P = 0.004). Conclusion: Plasma miR-146a expression levels in patients with UAP correlated with the severity of coronary lesions, and patients with high miR-146a expression levels had poorer clinical prognoses than those with lower expression levels.
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