ArticleCureus2024
The Pharmaceutical Composition of Rocuronium Bromide May Promote Catecholamine Release From PC-12 Cells.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral cases of pheochromocytoma presenting with hypertensive crises after anesthesia induction, possibly caused by rocuronium injection, have been reported. Rocuronium has two compositions: rocuronium bromide (RB) in sodium acetate hydrate/acetic acid buffer solution (acetic acid vehicle) and RB in glycine/hydrochloric acid buffer solution (hydrochloric acid vehicle). This study assessed the effect of rocuronium composition on the release of catecholamine from PC-12 rat adrenal pheochromocytoma cells.
methodsPC-12 cells (3x10
resultsRelease of NE and DA was caused by acetic acid vehicle, not by RB in PBS (-). Hydrochloric acid vehicles similarly showed a significantly lower release of NE and DA than acetic vehicle acid (NE, P=0.002; DA, P=0.002). In addition, the acetic acid vehicle diluted 5-fold with NS showed a significantly lower release of NE and DA than the acetic acid vehicle alone (NE, P=0.005; DA, P=0.002).
conclusionsThe concentration of acetic acid in the buffer solution, not RB, caused the release of catecholamines from PC-12 cells.
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