ArticleIn vitro models2023
The protective effect of endurance running against the pro-invasive effects of ageing in breast cancer cells and mesenchymal stem cells
Article in In vitro models, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Regular exercise is known to reduce cancer risk and may prevent metastases, however, modelling this Methods: Exercised serum from long-term trained younger and older endurance runners and sprinters was used to supplement cell culture media in the 3D culture of spheroids containing breast cancer cells or mesenchymal stem cells. Spheroids were generated in a 3D semi-solid matrix and cell invasion was measured using ImageJ software. Statistical analyses of invasion were conducted using one-way ANOVAs. Results: Invasion was significantly greater in cells cultured with serum from older, inactive participants compared to young, inactive participants (YC vs OC; F Conclusion: This is the first study of its kind to demonstrate the protective effects of long-term exercise training type in two populations of different ages against the invasiveness of breast cancer cells
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